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Himanshu Manchanda, Nora Seidel, Andi Krumbholz, Andreas Sauerbrei, Michaela Schmidtke & Reinhard Guthke. Within-host influenza dynamics: a small-scale mathematical modeling approach.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_virus_pathogenicity_p",
"label": "Initial Virus Pathogenicity P",
"units": "native source value",
"default": 0.01,
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.initial_virus_pathogenicity_p",
"description": "Initial Virus Pathogenicity P. Sets the initial value of bundled SBML species `P`."
},
{
"name": "initial_antiviral_immune_defense_d",
"label": "Initial Antiviral Immune Defense D",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.initial_antiviral_immune_defense_d",
"description": "Initial Antiviral Immune Defense D. Sets the initial value of bundled SBML species `D`."
},
{
"name": "initial_inflammation_i",
"label": "Initial Inflammation I",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.initial_inflammation_i",
"description": "Initial Inflammation I. Sets the initial value of bundled SBML species `I`."
},
{
"name": "infection_of_virus_rate",
"label": "Infection Of Virus Rate",
"units": "native source value",
"default": 3.63,
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.infection_of_virus_rate",
"description": "Infection Of Virus Rate. Sets bundled SBML parameter `alpha`."
}
],
"outputs": [
{
"name": "virus_pathogenicity_p",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.virus_pathogenicity_p"
},
{
"name": "antiviral_immune_defense_d",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.antiviral_immune_defense_d"
},
{
"name": "inflammation_i",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.inflammation_i"
},
{
"name": "clinical_score_s",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.clinical_score_s"
},
{
"name": "state",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.species_labels"
}
]
},
"title": "Manchanda2014 - Effect on Immune System by 4 different Influenza A virus strains Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model_state"
],
"from": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.state"
},
{
"to": [
"visualisation.immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model_summary"
],
"from": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model_species_labels"
],
"from": "immunology_sbml_manchanda2014_effect_on_immune_system_by_4_diffe_biomd0000000712_model.species_labels"
}
],
"package": "manchanda2014-effect-on-immune-system-by-4-different",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Himanshu Manchanda, Nora Seidel, Andi Krumbholz, Andreas Sauerbrei, Michaela Schmidtke & Reinhard Guthke. Within-host influenza dynamics: a small-scale mathematical modeling approach.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagemanchanda2014-effect-on-immune-system-by-4-different
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother