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A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum et al (2000) This paper includes three stages, and the model does not include the third stage. It can be used to explore systemsbiology blum2000 lhsecretion 1 BioModels0000000077 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_gq",
"label": "Initial Model State Gq",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.initial_model_state_gq",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `GQ`."
},
{
"name": "initial_model_state_ip3",
"label": "Initial Model State IP3",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.initial_model_state_ip3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IP3`."
},
{
"name": "initial_hrrh",
"label": "Initial Hrrh",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.initial_hrrh",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `HRRH`."
},
{
"name": "initial_model_state_hr",
"label": "Initial Model State Hr",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.initial_model_state_hr",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `HR`."
},
{
"name": "initial_model_state_cho",
"label": "Initial Model State Cho",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.initial_model_state_cho",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CHO`."
},
{
"name": "initial_model_state_h",
"label": "Initial Model State H",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.initial_model_state_h",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `H`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.species_labels"
},
{
"name": "model_state_gq",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.model_state_gq"
},
{
"name": "ip3",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.ip3"
},
{
"name": "hrrh",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.hrrh"
},
{
"name": "model_state_hr",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.model_state_hr"
},
{
"name": "cho",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.cho"
},
{
"name": "model_state_h",
"maps_to": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.model_state_h"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Blum2000 Lhsecretion 1 Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model_state"
],
"from": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model_summary"
],
"from": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model_species_labels"
],
"from": "systemsbiology_sbml_blum2000_lhsecretion_1_biomd0000000077_model.species_labels"
}
],
"package": "blum2000-lhsecretion-1",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum et al (2000) This paper includes three stages, and the model does not include the third stage. It can be used to explore systemsbiology blum2000 lhsecretion 1 BioModels0000000077 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageblum2000-lhsecretion-1
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother