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Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates mult.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_interleukin_7_receptor_jak1_stat5_complex",
"label": "Initial Interleukin 7 Receptor Jak1 Stat5 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1_stat5_complex",
"description": "Initial Interleukin 7 Receptor Jak1 Stat5 Complex. Sets the initial value of bundled SBML species `IL7IL7RpJAK1STAT5`."
},
{
"name": "initial_interleukin_7_receptor_jak1_complex",
"label": "Initial Interleukin 7 Receptor Jak1 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1_complex",
"description": "Initial Interleukin 7 Receptor Jak1 Complex. Sets the initial value of bundled SBML species `IL7IL7RJAK1`."
},
{
"name": "initial_interleukin_7_receptor_jak1",
"label": "Initial Interleukin 7 Receptor Jak1",
"units": "substance",
"default": 1.66053904042716,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1",
"description": "Initial Interleukin 7 Receptor Jak1. Sets the initial value of bundled SBML species `IL7RJAK1`."
},
{
"name": "initial_phosphorylated_interleukin_7_receptor_jak1_complex",
"label": "Initial Phosphorylated Interleukin 7 Receptor Jak1 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_phosphorylated_interleukin_7_receptor_jak1_complex",
"description": "Initial Phosphorylated Interleukin 7 Receptor Jak1 Complex. Sets the initial value of bundled SBML species `IL7IL7RpJAK1`."
},
{
"name": "initial_interleukin_7_receptor_jak1_socs1_complex",
"label": "Initial Interleukin 7 Receptor Jak1 Socs1 Complex",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.initial_interleukin_7_receptor_jak1_socs1_complex",
"description": "Initial Interleukin 7 Receptor Jak1 Socs1 Complex. Sets the initial value of bundled SBML species `IL7IL7RpJAK1SOCS1`."
}
],
"outputs": [
{
"name": "interleukin_7_receptor_jak1_stat5_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1_stat5_complex"
},
{
"name": "interleukin_7_receptor_jak1_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1_complex"
},
{
"name": "interleukin_7_receptor_jak1",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1"
},
{
"name": "phosphorylated_interleukin_7_receptor_jak1_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.phosphorylated_interleukin_7_receptor_jak1_complex"
},
{
"name": "interleukin_7_receptor_jak1_socs1_complex",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.interleukin_7_receptor_jak1_socs1_complex"
},
{
"name": "state",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.species_labels"
}
]
},
"title": "Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model_state"
],
"from": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.state"
},
{
"to": [
"visualisation.immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model_summary"
],
"from": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model_species_labels"
],
"from": "immunology_sbml_palmer2008_negative_feedback_in_il_7_mediated_ja_biomd0000000968_model.species_labels"
}
],
"package": "palmer2008-negative-feedback-in-il-7-mediated-jak",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates mult.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagepalmer2008-negative-feedback-in-il-7-mediated-jak
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother