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This model is from the article: Genetic and metabolic determinants of nutritional phenotype in an insect-bacterial symbiosis. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_metabolic_pathway_state_1",
"units": "native SBML value",
"default": 0,
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.initial_metabolic_pathway_state_1",
"description": "Initial condition for metabolic pathway state 1. Maps to bundled SBML symbol `ser__45__L_c_`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
},
{
"name": "initial_tetrahydrofolate",
"units": "native SBML value",
"default": 0,
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.initial_tetrahydrofolate",
"description": "Initial condition for tetrahydrofolate. Maps to bundled SBML symbol `thf_c_`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
},
{
"name": "initial_metabolic_pathway_state_3",
"units": "native SBML value",
"default": 0,
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.initial_metabolic_pathway_state_3",
"description": "Initial condition for metabolic pathway state 3. Maps to bundled SBML symbol `gly_c_`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
},
{
"name": "initial_h2o",
"units": "native SBML value",
"default": 0,
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.initial_h2o",
"description": "Initial condition for h2o. Maps to bundled SBML symbol `h2o_c_`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
},
{
"name": "initial_metabolic_pathway_state_5",
"units": "native SBML value",
"default": 0,
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.initial_metabolic_pathway_state_5",
"description": "Initial condition for metabolic pathway state 5. Maps to bundled SBML symbol `mlthf_c_`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
}
],
"outputs": [
{
"name": "metabolic_pathway_state_1",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.metabolic_pathway_state_1"
},
{
"name": "tetrahydrofolate",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.tetrahydrofolate"
},
{
"name": "metabolic_pathway_state_3",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.metabolic_pathway_state_3"
},
{
"name": "h2o",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.h2o"
},
{
"name": "metabolic_pathway_state_5",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.metabolic_pathway_state_5"
},
{
"name": "observable_values",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.observable_values"
},
{
"name": "run_summary",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.run_summary"
},
{
"name": "observable_labels",
"maps_to": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.observable_labels"
}
]
},
"title": "MacDonald2011_GeneticMetabolicDeterminants_BuchnereAphidicola Lab",
"models": [
{
"path": "models/core",
"alias": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model",
"parameters": {
"model_path": "data/MODEL1012300000.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model_observable_values"
],
"from": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.observable_values"
},
{
"to": [
"visualisation.metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model_run_summary"
],
"from": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.run_summary"
},
{
"to": [
"visualisation.metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model_observable_labels"
],
"from": "metabolism_sbml_macdonald2011_geneticmetabolicdeterminants_buchn_model1012300000_model.observable_labels"
}
],
"package": "macdonald2011-geneticmetabolicdeterminants-buchnereaphidicola",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This model is from the article: Genetic and metabolic determinants of nutritional phenotype in an insect-bacterial symbiosis. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagemacdonald2011-geneticmetabolicdeterminants-buchnereaphidicola
Created2026-05-15
Updated2026-06-13
biomodels_ebifaithfulmetabolismodesbmltelluriumvisualisationother