Irvine1999 Cardiac Sodium Channel Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "irvine1999_cardiac_sodium_channel_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "irvine1999_cardiac_sodium_channel_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "irvine1999_cardiac_sodium_channel_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "irvine1999_cardiac_sodium_channel_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "irvine1999_cardiac_sodium_channel_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "irvine1999_cardiac_sodium_channel_viz.run_summary"
      }
    ]
  },
  "title": "Irvine1999 Cardiac Sodium Channel Lab",
  "models": [
    {
      "path": "models/scenario",
      "alias": "irvine1999_cardiac_sodium_channel_scenario",
      "parameters": {
        "schedule": {
          "holding_voltage": {
            "unit": "mV",
            "label": "holding voltage",
            "active": true,
            "baseline": -0.12,
            "recovery": -0.12,
            "challenge": -0.02,
            "description": "Scenario-controlled holding voltage value."
          },
          "sodium_conductance": {
            "unit": "mS_per_uF",
            "label": "sodium conductance",
            "active": false,
            "baseline": 0.0131,
            "recovery": 0.0131,
            "challenge": 0.0131,
            "description": "Scenario-controlled sodium conductance value."
          },
          "sodium_reversal_voltage": {
            "unit": "mV",
            "label": "sodium reversal voltage",
            "active": false,
            "baseline": 0.044675,
            "recovery": 0.044675,
            "challenge": 0.044675,
            "description": "Scenario-controlled sodium reversal voltage value."
          }
        },
        "scenario_name": "Voltage-step channel challenge",
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a holding voltage challenge and recovery period."
      }
    },
    {
      "path": "./models/core",
      "alias": "irvine1999_cardiac_sodium_channel_core",
      "parameters": {
        "model_path": "data/MODEL0848062679.xml",
        "integration_step": 0.001
      }
    },
    {
      "path": "./models/viz",
      "alias": "irvine1999_cardiac_sodium_channel_viz",
      "parameters": {
        "lab_title": "Irvine1999 Cardiac Sodium Channel",
        "lab_question": "How does the cardiac sodium channel recover and inactivate?",
        "integration_step": 0.001
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "irvine1999_cardiac_sodium_channel_core.holding_voltage"
      ],
      "from": "irvine1999_cardiac_sodium_channel_scenario.holding_voltage"
    },
    {
      "to": [
        "irvine1999_cardiac_sodium_channel_core.sodium_reversal_voltage"
      ],
      "from": "irvine1999_cardiac_sodium_channel_scenario.sodium_reversal_voltage"
    },
    {
      "to": [
        "irvine1999_cardiac_sodium_channel_core.sodium_conductance"
      ],
      "from": "irvine1999_cardiac_sodium_channel_scenario.sodium_conductance"
    },
    {
      "to": [
        "irvine1999_cardiac_sodium_channel_viz.scenario_metadata"
      ],
      "from": "irvine1999_cardiac_sodium_channel_scenario.scenario_metadata"
    },
    {
      "to": [
        "irvine1999_cardiac_sodium_channel_viz.state"
      ],
      "from": "irvine1999_cardiac_sodium_channel_core.state"
    },
    {
      "to": [
        "irvine1999_cardiac_sodium_channel_viz.species_labels"
      ],
      "from": "irvine1999_cardiac_sodium_channel_core.species_labels"
    }
  ],
  "package": "irvine1999-cardiac-sodium-channel",
  "runtime": {
    "duration": 1,
    "initial_inputs": {
      "irvine1999_cardiac_sodium_channel_core": {
        "integration_step": 0.001,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.001
  },
  "version": "1.0.0",
  "description": "Two-model lab for Irvine1999 Cardiac Sodium Channel: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Cardiac sodium channel Markov model with temperature dependence and recoveryfrom inactivation. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}