Iwamoto2010 - Cell cycle reponse to DNA damage Lab

{
  "io": {
    "inputs": [
      {
        "name": "dna_damage_signal_source_parameter",
        "label": "DNA damage signal source parameter",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.dna_damage_signal_source_parameter",
        "description": "DNA damage signal source parameter. Maps to bundled SBML parameter `DNA_damage_signal`."
      },
      {
        "name": "initial_p27_cyclin_d_cdk4",
        "label": "P27/CyclinD/Cdk4",
        "units": "native SBML value",
        "default": 0.001,
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.initial_p27_cyclin_d_cdk4",
        "description": "Initial P27/CyclinD/Cdk4. Sets the initial value of bundled SBML symbol `p27_CyclinD_Cdk4`."
      },
      {
        "name": "initial_p27_cyclin_e_cdk2",
        "label": "P27/CyclinE/Cdk2",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.initial_p27_cyclin_e_cdk2",
        "description": "Initial P27/CyclinE/Cdk2. Sets the initial value of bundled SBML symbol `p27_CyclinE_Cdk2`."
      },
      {
        "name": "initial_p27_cyclin_a_cdk2",
        "label": "P27/CyclinA/Cdk2",
        "units": "native SBML value",
        "default": 0.0001,
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.initial_p27_cyclin_a_cdk2",
        "description": "Initial P27/CyclinA/Cdk2. Sets the initial value of bundled SBML symbol `p27_CyclinA_Cdk2`."
      },
      {
        "name": "initial_p21_cyclin_d_cdk4",
        "label": "P21/CyclinD/Cdk4",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.initial_p21_cyclin_d_cdk4",
        "description": "Initial P21/CyclinD/Cdk4. Sets the initial value of bundled SBML symbol `p21_CyclinD_Cdk4`."
      },
      {
        "name": "initial_p21_cyclin_e_cdk2",
        "label": "P21/CyclinE/Cdk2",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.initial_p21_cyclin_e_cdk2",
        "description": "Initial P21/CyclinE/Cdk2. Sets the initial value of bundled SBML symbol `p21_CyclinE_Cdk2`."
      }
    ],
    "outputs": [
      {
        "name": "p27_cyclin_d_cdk4",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.p27_cyclin_d_cdk4",
        "description": "P27/CyclinD/Cdk4 observable. Maps to SBML symbol `p27_CyclinD_Cdk4`."
      },
      {
        "name": "p27_cyclin_e_cdk2",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.p27_cyclin_e_cdk2",
        "description": "P27/CyclinE/Cdk2 observable. Maps to SBML symbol `p27_CyclinE_Cdk2`."
      },
      {
        "name": "p27_cyclin_a_cdk2",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.p27_cyclin_a_cdk2",
        "description": "P27/CyclinA/Cdk2 observable. Maps to SBML symbol `p27_CyclinA_Cdk2`."
      },
      {
        "name": "p21_cyclin_d_cdk4",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.p21_cyclin_d_cdk4",
        "description": "P21/CyclinD/Cdk4 observable. Maps to SBML symbol `p21_CyclinD_Cdk4`."
      },
      {
        "name": "p21_cyclin_e_cdk2",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.p21_cyclin_e_cdk2",
        "description": "P21/CyclinE/Cdk2 observable. Maps to SBML symbol `p21_CyclinE_Cdk2`."
      },
      {
        "name": "p21_cyclin_a_cdk2",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.p21_cyclin_a_cdk2",
        "description": "P21/CyclinA/Cdk2 observable. Maps to SBML symbol `p21_CyclinA_Cdk2`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "cellcycle",
    "curated",
    "dna-damage",
    "faithful",
    "oncology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Iwamoto2010 - Cell cycle reponse to DNA damage Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model_state"
      ],
      "from": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model_summary"
      ],
      "from": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model_species_labels"
      ],
      "from": "oncology_sbml_iwamoto2010_cell_cycle_reponse_to_dna_damage_biomd0000000939_model.species_labels"
    }
  ],
  "package": "iwamoto2010-cell-cycle-reponse-to-dna-damage",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "After DNA damage, cells activate p53, a tumor suppressor gene, and select a cell fate (e.g., DNA repair, cell cycle arrest, or apoptosis). Recently, a p53 oscillatory behavior was observed following D.",
  "schema_version": "2.0"
}