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Source-faithful physiology lab for Bonhoeffer, Rembiszewski, Ortiz, Nixon, 2000. Public controls and outputs are mapped to real source symbols for source-model physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_ctl",
"label": "Initial CTL",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.initial_ctl",
"description": "Initial value for CTL. Maps to source symbol `E`. Units: dimensionless. Naming evidence: source metadata names `E` as `CTL`.",
"accepted_units": [
"dimensionless"
]
},
{
"name": "initial_infected_cells",
"label": "Initial Infected Cells",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.initial_infected_cells",
"description": "Initial value for Infected Cells. Maps to source symbol `I`. Units: dimensionless. Naming evidence: source metadata names `I` as `infected cells`.",
"accepted_units": [
"dimensionless"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.variable_labels"
},
{
"name": "ctl",
"label": "CTL",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.ctl",
"description": "CTL. Maps to source symbol `E`. Units: dimensionless. Naming evidence: source metadata names `E` as `CTL`."
},
{
"name": "infected_cells",
"label": "Infected Cells",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.infected_cells",
"description": "Infected Cells. Maps to source symbol `I`. Units: dimensionless. Naming evidence: source metadata names `I` as `infected cells`."
},
{
"name": "susceptible_target_cells",
"label": "Susceptible Target Cells",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.susceptible_target_cells",
"description": "Susceptible Target Cells. Maps to source symbol `T`. Units: dimensionless. Naming evidence: source metadata names `T` as `susceptible target cells`."
},
{
"name": "model_parameter_k",
"label": "Model Parameter K (source K)",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.model_parameter_k",
"description": "Model Parameter K (source K). Maps to source symbol `K`. Units: dimensionless. Naming evidence: source symbol is dimensionless but lacks enough evidence for a biological label."
},
{
"name": "rate_constant_d_e",
"label": "Rate Constant D E (source dE)",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.rate_constant_d_e",
"description": "Rate Constant D E (source dE). Maps to source symbol `dE`. Units: first_order_rate_constant. Naming evidence: units identify a rate constant but not a fuller biological role."
},
{
"name": "rate_constant_d_i",
"label": "Rate Constant D I (source dI)",
"maps_to": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.rate_constant_d_i",
"description": "Rate Constant D I (source dI). Maps to source symbol `dI`. Units: first_order_rate_constant. Naming evidence: units identify a rate constant but not a fuller biological role."
}
]
},
"title": "Bonhoeffer2000 - Risks Benefits Structured Antiretroviral D Bonhoefferremb Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model",
"parameters": {
"model_path": "data/bonhoeffer_rembiszewski_ortiz_nixon_2000_a.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model_state"
],
"from": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.state"
},
{
"to": [
"visualisation.physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model_summary"
],
"from": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model_trajectory"
],
"from": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model_variable_labels"
],
"from": "physiology_cellml_bonhoeffer_rembiszewski_ortiz_nixon_2000_bonhoefferrembiszewskiortiznixon2000_model.variable_labels"
}
],
"package": "bonhoeffer2000-risks-benefits-structured-antiretroviral-b7f5c86a",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Source-faithful physiology lab for Bonhoeffer, Rembiszewski, Ortiz, Nixon, 2000. Public controls and outputs are mapped to real source symbols for source-model physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagebonhoeffer2000-risks-benefits-structured-antiretroviral-b7f5c86a
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother