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This is the reduced kidney metabolic network described in the article Drug off-target effects predicted using structural analysis in the context of a metabolic network model. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cytosolic_atp",
"label": "Initial Cytosolic ATP",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_cytosolic_atp"
},
{
"name": "initial_mitochondrial_atp",
"label": "Initial Mitochondrial ATP",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_mitochondrial_atp"
},
{
"name": "initial_extracellular_glucose",
"label": "Initial Extracellular Glucose",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_extracellular_glucose"
},
{
"name": "initial_cytosolic_lactate",
"label": "Initial Cytosolic Lactate",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.initial_cytosolic_lactate"
}
],
"outputs": [
{
"name": "state",
"label": "Tracked source state",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.species_labels"
},
{
"name": "cytosolic_atp",
"label": "Cytosolic ATP",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_atp"
},
{
"name": "mitochondrial_atp",
"label": "Mitochondrial ATP",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.mitochondrial_atp"
},
{
"name": "cytosolic_glucose",
"label": "Cytosolic Glucose",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_glucose"
},
{
"name": "extracellular_glucose",
"label": "Extracellular Glucose",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.extracellular_glucose"
},
{
"name": "cytosolic_lactate",
"label": "Cytosolic Lactate",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_lactate"
},
{
"name": "extracellular_lactate",
"label": "Extracellular Lactate",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.extracellular_lactate"
},
{
"name": "cytosolic_urea",
"label": "Cytosolic Urea",
"maps_to": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.cytosolic_urea"
}
]
},
"tags": [
"pharmacology",
"metabolism",
"kidney",
"systems-biology",
"fba",
"sbml",
"tellurium",
"faithful",
"biomodels_ebi"
],
"title": "Chang2010_Reduced_Kidney_FBA Lab",
"models": [
{
"path": "models/core",
"alias": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model",
"parameters": {
"model_path": "data/MODEL1011080004.xml",
"integration_step": 0.05
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model_state"
],
"from": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.state"
},
{
"to": [
"visualisation.pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model_summary"
],
"from": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.summary"
},
{
"to": [
"visualisation.pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model_species_labels"
],
"from": "pharmacology_sbml_chang2010_reduced_kidney_fba_model1011080004_model.species_labels"
}
],
"package": "chang2010-kidney-fba",
"runtime": {
"duration": 5,
"initial_inputs": {},
"communication_step": 0.5
},
"version": "1.0.0",
"description": "This is the reduced kidney metabolic network described in the article Drug off-target effects predicted using structural analysis in the context of a metabolic network model. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
"schema_version": "2.0"
}Runtime
Duration5
Comms Step0.5
Runs
Total0
Completed0
Failed0
Metadata
Packagechang2010-kidney-fba
Created2026-05-16
Updated2026-06-13
pharmacologymetabolismkidneysystems-biologyfbasbmltelluriumfaithfulbiomodels_ebivisualisationother