Intosalmi2015 Th17 Differentiation Network Lab

{
  "io": {
    "inputs": [
      {
        "name": "starting_interleukin_6_signal",
        "label": "Starting IL-6 signal",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "intosalmi2015_th17_network.starting_interleukin_6_signal",
        "description": "Setup-time initial extracellular IL-6 signal for the Th17 network. Maps to SBML symbol `IL6ext`."
      },
      {
        "name": "starting_transforming_growth_factor_beta_signal",
        "label": "Starting TGF-beta signal",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "intosalmi2015_th17_network.starting_transforming_growth_factor_beta_signal",
        "description": "Setup-time initial extracellular TGF-beta signal for the Th17 network. Maps to SBML symbol `TGFbext`."
      }
    ],
    "outputs": [
      {
        "name": "external_interleukin_6",
        "label": "External IL-6",
        "maps_to": "intosalmi2015_th17_network.external_interleukin_6",
        "description": "External IL-6. Maps to SBML symbol `IL6ext`."
      },
      {
        "name": "internal_interleukin_6",
        "label": "Internal IL-6",
        "maps_to": "intosalmi2015_th17_network.internal_interleukin_6",
        "description": "Internal IL-6. Maps to SBML symbol `IL6int`."
      },
      {
        "name": "signal_transducer_and_activator_of_transcription_3_messenger_rna",
        "label": "STAT3 mRNA",
        "maps_to": "intosalmi2015_th17_network.signal_transducer_and_activator_of_transcription_3_messenger_rna",
        "description": "STAT3 mRNA. Maps to SBML symbol `STAT3mRNA`."
      },
      {
        "name": "active_signal_transducer_and_activator_of_transcription_3",
        "label": "Active STAT3",
        "maps_to": "intosalmi2015_th17_network.active_signal_transducer_and_activator_of_transcription_3",
        "description": "Active STAT3. Maps to SBML symbol `STAT3prot_star`."
      },
      {
        "name": "external_transforming_growth_factor_beta",
        "label": "External TGF-beta",
        "maps_to": "intosalmi2015_th17_network.external_transforming_growth_factor_beta",
        "description": "External TGF-beta. Maps to SBML symbol `TGFbext`."
      },
      {
        "name": "internal_transforming_growth_factor_beta",
        "label": "Internal TGF-beta",
        "maps_to": "intosalmi2015_th17_network.internal_transforming_growth_factor_beta",
        "description": "Internal TGF-beta. Maps to SBML symbol `TGFbint`."
      },
      {
        "name": "retinoic_acid_receptor_related_orphan_receptor_gamma_t_messenger_rna",
        "label": "ROR-gamma-t mRNA",
        "maps_to": "intosalmi2015_th17_network.retinoic_acid_receptor_related_orphan_receptor_gamma_t_messenger_rna",
        "description": "ROR-gamma-t mRNA. Maps to SBML symbol `RORgtmRNA`."
      },
      {
        "name": "active_forkhead_box_p3",
        "label": "Active FOXP3",
        "maps_to": "intosalmi2015_th17_network.active_forkhead_box_p3",
        "description": "Active FOXP3. Maps to SBML symbol `FOXP3prot_star`."
      },
      {
        "name": "forkhead_box_p3_messenger_rna",
        "label": "FOXP3 mRNA",
        "maps_to": "intosalmi2015_th17_network.forkhead_box_p3_messenger_rna",
        "description": "FOXP3 mRNA. Maps to SBML symbol `FOXP3mRNA`."
      },
      {
        "name": "state",
        "maps_to": "intosalmi2015_th17_network.state",
        "description": "Full friendly observable record."
      },
      {
        "name": "summary",
        "maps_to": "intosalmi2015_th17_network.summary",
        "description": "Core model run summary."
      },
      {
        "name": "species_labels",
        "maps_to": "intosalmi2015_th17_network.species_labels",
        "description": "Friendly observable display labels."
      }
    ]
  },
  "title": "Intosalmi2015 Th17 Differentiation Network Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "intosalmi2015_th17_network",
      "parameters": {
        "model_path": "data/BIOMD0000001004.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.core_state"
      ],
      "from": "intosalmi2015_th17_network.state"
    },
    {
      "to": [
        "visualisation.core_summary"
      ],
      "from": "intosalmi2015_th17_network.summary"
    },
    {
      "to": [
        "visualisation.core_species_labels"
      ],
      "from": "intosalmi2015_th17_network.species_labels"
    }
  ],
  "package": "intosalmi2015-th17-differentiation-network",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Core molecular network steering Th17 cell differentiation executed directly from the bundled SBML source.",
  "schema_version": "2.0"
}