Guyton1972 Heart Hypertrophy Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "guyton1972_heart_hypertrophy_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "guyton1972_heart_hypertrophy_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "guyton1972_heart_hypertrophy_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "guyton1972_heart_hypertrophy_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "guyton1972_heart_hypertrophy_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "guyton1972_heart_hypertrophy_viz.run_summary"
      }
    ]
  },
  "title": "Guyton1972 Heart Hypertrophy Lab",
  "models": [
    {
      "path": "models/scenario",
      "alias": "guyton1972_heart_hypertrophy_scenario",
      "parameters": {
        "schedule": {
          "aortic_flow": {
            "unit": "dimensionless",
            "label": "aortic flow",
            "active": false,
            "baseline": 5.00707,
            "recovery": 5.00707,
            "challenge": 5.00707,
            "description": "Scenario-controlled aortic flow value."
          },
          "arterial_pressure": {
            "unit": "dimensionless",
            "label": "arterial pressure",
            "active": true,
            "baseline": 103.525,
            "recovery": 103.525,
            "challenge": 124.23,
            "description": "Scenario-controlled arterial pressure value."
          },
          "pulmonary_artery_pressure": {
            "unit": "dimensionless",
            "label": "pulmonary artery pressure",
            "active": false,
            "baseline": 15.6376,
            "recovery": 15.6376,
            "challenge": 15.6376,
            "description": "Scenario-controlled pulmonary artery pressure value."
          }
        },
        "scenario_name": "Pressure-load challenge",
        "baseline_until": 150,
        "challenge_until": 450,
        "scenario_description": "Baseline is followed by a arterial pressure challenge and recovery period."
      }
    },
    {
      "path": "./models/core",
      "alias": "guyton1972_heart_hypertrophy_core",
      "parameters": {
        "model_path": "data/MODEL0911231713.xml",
        "integration_step": 1
      }
    },
    {
      "path": "./models/viz",
      "alias": "guyton1972_heart_hypertrophy_viz",
      "parameters": {
        "lab_title": "Guyton1972 Heart Hypertrophy",
        "lab_question": "Does sustained workload drive hypertrophy?",
        "integration_step": 1
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "guyton1972_heart_hypertrophy_core.aortic_flow"
      ],
      "from": "guyton1972_heart_hypertrophy_scenario.aortic_flow"
    },
    {
      "to": [
        "guyton1972_heart_hypertrophy_core.arterial_pressure"
      ],
      "from": "guyton1972_heart_hypertrophy_scenario.arterial_pressure"
    },
    {
      "to": [
        "guyton1972_heart_hypertrophy_core.pulmonary_artery_pressure"
      ],
      "from": "guyton1972_heart_hypertrophy_scenario.pulmonary_artery_pressure"
    },
    {
      "to": [
        "guyton1972_heart_hypertrophy_viz.scenario_metadata"
      ],
      "from": "guyton1972_heart_hypertrophy_scenario.scenario_metadata"
    },
    {
      "to": [
        "guyton1972_heart_hypertrophy_viz.state"
      ],
      "from": "guyton1972_heart_hypertrophy_core.state"
    },
    {
      "to": [
        "guyton1972_heart_hypertrophy_viz.species_labels"
      ],
      "from": "guyton1972_heart_hypertrophy_core.species_labels"
    }
  ],
  "package": "guyton1972-heart-hypertrophy",
  "runtime": {
    "duration": 600,
    "initial_inputs": {
      "guyton1972_heart_hypertrophy_core": {
        "integration_step": 1,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Two-model lab for Guyton1972 Heart Hypertrophy: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}