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Source-faithful physiology lab for Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005. Public controls and outputs are mapped to real source symbols for source-model physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_egf",
"label": "Initial Egf",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.initial_egf",
"description": "Initial value for Egf. Maps to source symbol `c1`. Units: molar. Naming evidence: source metadata names `c1` as `EGF`.",
"accepted_units": [
"molar"
]
},
{
"name": "initial_egf_egfr",
"label": "Initial Egf Egfr",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.initial_egf_egfr",
"description": "Initial value for Egf Egfr. Maps to source symbol `c3`. Units: molar. Naming evidence: source metadata names `c3` as `EGF-EGFR`.",
"accepted_units": [
"molar"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.variable_labels"
},
{
"name": "egf_egfri",
"label": "Egf Egfri",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.egf_egfri",
"description": "Egf Egfri. Maps to source symbol `c10`. Units: molar. Naming evidence: source metadata names `c10` as `EGF-EGFRi`."
},
{
"name": "egf_egfri_2_c11",
"label": "Egf Egfri 2 C11",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.egf_egfri_2_c11",
"description": "Egf Egfri 2 C11. Maps to source symbol `c11`. Units: molar. Naming evidence: source metadata names `c11` as `(EGF-EGFRi)2`."
},
{
"name": "egf_egfri_2_gap_grb2_sos_deg",
"label": "Egf Egfri 2 Gap Grb2 Sos Deg",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.egf_egfri_2_gap_grb2_sos_deg",
"description": "Egf Egfri 2 Gap Grb2 Sos Deg. Maps to source symbol `c100`. Units: molar. Naming evidence: source metadata names `c100` as `(EGF-EGFRi*)2-GAP-Grb2-Sos-deg`."
},
{
"name": "sos_erk_pp",
"label": "Sos Erk Pp",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.sos_erk_pp",
"description": "Sos Erk Pp. Maps to source symbol `c101`. Units: molar. Naming evidence: source metadata names `c101` as `Sos-ERK-PP`."
},
{
"name": "sos_erki_pp",
"label": "Sos Erki Pp",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.sos_erki_pp",
"description": "Sos Erki Pp. Maps to source symbol `c102`. Units: molar. Naming evidence: source metadata names `c102` as `Sos-ERKi-PP`."
},
{
"name": "sosi",
"label": "Sosi",
"maps_to": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.sosi",
"description": "Sosi. Maps to source symbol `c103`. Units: molar. Naming evidence: source metadata names `c103` as `Sosi`."
}
]
},
"title": "Hornberg2005 - Hornberg Binder Bruggeman Schoeberl Heinrich Wes Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model",
"parameters": {
"model_path": "data/hornberg_binder_bruggeman_schoeberl_heinrich_westerhoff_2005.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_state"
],
"from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.state"
},
{
"to": [
"visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_summary"
],
"from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_trajectory"
],
"from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model_variable_labels"
],
"from": "physiology_cellml_hornberg_binder_bruggeman_schoeberl_heinrich_wes_hornbergbinderbruggemanschoeberlheinrichwesterhoff2005_model.variable_labels"
}
],
"package": "hornberg2005-hornberg-binder-bruggeman-schoeberl-heinrich-wes",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Source-faithful physiology lab for Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005. Public controls and outputs are mapped to real source symbols for source-model physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagehornberg2005-hornberg-binder-bruggeman-schoeberl-heinrich-wes
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother