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Martinez-Guimera2017 - Generic negative feedback circuit (Model 4) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. It can be used to explore systemsbiology martinez guimera2017 generic negative feedback dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_nil",
"label": "Initial Model State Nil",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.initial_model_state_nil",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Nil`."
},
{
"name": "initial_model_state_s",
"label": "Initial Model State S",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.initial_model_state_s",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S`."
},
{
"name": "initial_model_state_o",
"label": "Initial Model State O",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.initial_model_state_o",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `O`."
},
{
"name": "initial_model_state_n",
"label": "Initial Model State N",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.initial_model_state_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `N`."
},
{
"name": "initial_model_state_f",
"label": "Initial Model State F",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.initial_model_state_f",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `F`."
},
{
"name": "initial_model_state_a",
"label": "Initial Model State A",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.initial_model_state_a",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.species_labels"
},
{
"name": "nil",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.nil"
},
{
"name": "model_state_s",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.model_state_s"
},
{
"name": "model_state_o",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.model_state_o"
},
{
"name": "model_state_n",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.model_state_n"
},
{
"name": "model_state_f",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.model_state_f"
},
{
"name": "model_state_a",
"maps_to": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.model_state_a"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Martinez Guimera2017 Generic Negative Feedback Circuit Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model_state"
],
"from": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model_summary"
],
"from": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model_species_labels"
],
"from": "systemsbiology_sbml_martinez_guimera2017_generic_negative_feedback_c_model1710260003_model.species_labels"
}
],
"package": "martinez-guimera2017-generic-negative-feedback-circuit",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Martinez-Guimera2017 - Generic negative feedback circuit (Model 4) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. It can be used to explore systemsbiology martinez guimera2017 generic negative feedback dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagemartinez-guimera2017-generic-negative-feedback-circuit
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother