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From a previous microarray study we developed a small chondrogenesis model. We performed qPCR and measured how knockdown of miR-199a-5p or miR-199b-5p could modulate chondrogenesis.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cav1",
"label": "Initial Cav1",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.initial_cav1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Cav1`."
},
{
"name": "initial_acan",
"label": "Initial Acan",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.initial_acan",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Acan`."
},
{
"name": "initial_tgfb3",
"label": "Initial Tgfb3",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.initial_tgfb3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TGFB3`."
},
{
"name": "initial_mir199a_5p",
"label": "Initial Mir199a 5P",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.initial_mir199a_5p",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MIR199a_5p`."
},
{
"name": "initial_sox9mrna",
"label": "Initial Sox9mrna",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.initial_sox9mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Sox9mRNA`."
},
{
"name": "initial_mir140_5p",
"label": "Initial Mir140 5P",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.initial_mir140_5p",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MIR140_5p`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.species_labels"
},
{
"name": "cav1",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.cav1"
},
{
"name": "acan",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.acan"
},
{
"name": "tgfb3",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.tgfb3"
},
{
"name": "mir199a_5p",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.mir199a_5p"
},
{
"name": "sox9mrna",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.sox9mrna"
},
{
"name": "mir140_5p",
"maps_to": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.mir140_5p"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Patel2023 Mirna 199a B 5p Regionation Of Chondrogenesis Enchanced Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model_state"
],
"from": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model_summary"
],
"from": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model_species_labels"
],
"from": "systemsbiology_sbml_patel2023_mirna_199a_b_5p_regionation_of_chondro_model2305010001_model.species_labels"
}
],
"package": "patel2023-mirna-199a-b-5p-regionation-of-chondrogenesis-0ac0f865",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "From a previous microarray study we developed a small chondrogenesis model. We performed qPCR and measured how knockdown of miR-199a-5p or miR-199b-5p could modulate chondrogenesis.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagepatel2023-mirna-199a-b-5p-regionation-of-chondrogenesis-0ac0f865
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother