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This is system 1, the model with linear antigen uptake by pAPCs, described in the article: Self-tolerance and Autoimmunity in a Regulatory T Cell Model. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_immune_observable_1",
"label": "Initial Unresolved Immune Observable 1",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.initial_unresolved_immune_observable_1",
"description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `A`."
},
{
"name": "initial_unresolved_immune_observable_2",
"label": "Initial Unresolved Immune Observable 2",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.initial_unresolved_immune_observable_2",
"description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `R`."
},
{
"name": "initial_unresolved_immune_observable_3",
"label": "Initial Unresolved Immune Observable 3",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.initial_unresolved_immune_observable_3",
"description": "Initial Unresolved Immune Observable 3. Sets the initial value of bundled SBML species `E`."
},
{
"name": "initial_unresolved_immune_observable_4",
"label": "Initial Unresolved Immune Observable 4",
"units": "native source value",
"default": 100000000,
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.initial_unresolved_immune_observable_4",
"description": "Initial Unresolved Immune Observable 4. Sets the initial value of bundled SBML species `G`."
},
{
"name": "r2_self_antigen_release_triggered_by_e_rate",
"label": "R2 Self Antigen Release Triggered By E Rate",
"units": "per_day",
"default": 2000,
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.r2_self_antigen_release_triggered_by_e_rate",
"description": "R2 Self Antigen Release Triggered By E Rate. Sets bundled SBML parameter `gamma`."
}
],
"outputs": [
{
"name": "unresolved_immune_observable_1",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.unresolved_immune_observable_1"
},
{
"name": "unresolved_immune_observable_2",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.unresolved_immune_observable_2"
},
{
"name": "unresolved_immune_observable_3",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.unresolved_immune_observable_3"
},
{
"name": "unresolved_immune_observable_4",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.unresolved_immune_observable_4"
},
{
"name": "unresolved_immune_observable_5",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.unresolved_immune_observable_5"
},
{
"name": "state",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.species_labels"
}
]
},
"title": "Alexander2010 Tcell Regulation Sys1 Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model_state"
],
"from": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.state"
},
{
"to": [
"visualisation.immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model_summary"
],
"from": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model_species_labels"
],
"from": "immunology_sbml_alexander2010_tcell_regulation_sys1_biomd0000000289_model.species_labels"
}
],
"package": "alexander2010-tcell-regulation-sys1",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "This is system 1, the model with linear antigen uptake by pAPCs, described in the article: Self-tolerance and Autoimmunity in a Regulatory T Cell Model. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagealexander2010-tcell-regulation-sys1
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother