Lopez2014 - A Validated Mathematical Model of Tumor Growth Including Tumor-Host Interaction and Cell-Mediated Immune Response Lab
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This is a dynamical model of cancer growth that includes three interacting cell populations of tumor cells, healthy host cells and immune effector cells. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tumor_cells",
"label": "Initial Tumor Cells",
"units": "native source value",
"default": 0.1,
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.initial_tumor_cells",
"description": "Initial Tumor Cells. Sets the initial value of bundled SBML species `x_Tumor_Cells`."
},
{
"name": "initial_effector_cells",
"label": "Initial Effector Cells",
"units": "native source value",
"default": 0.2,
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.initial_effector_cells",
"description": "Initial Effector Cells. Sets the initial value of bundled SBML species `z_Effector_Cells`."
},
{
"name": "initial_healthy_cells",
"label": "Initial Healthy Cells",
"units": "native source value",
"default": 0.9,
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.initial_healthy_cells",
"description": "Initial Healthy Cells. Sets the initial value of bundled SBML species `y_Healthy_Cells`."
},
{
"name": "effector_death_rate",
"label": "Effector Death Rate",
"units": "native source value",
"default": 0.112,
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.effector_death_rate",
"description": "Effector Death Rate. Sets bundled SBML parameter `d_3`."
}
],
"outputs": [
{
"name": "tumor_cells",
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.tumor_cells"
},
{
"name": "effector_cells",
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.effector_cells"
},
{
"name": "healthy_cells",
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.healthy_cells"
},
{
"name": "state",
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.species_labels"
}
]
},
"title": "Lopez2014 - A Validated Mathematical Model of Tumor Growth Including Tumor-Host Interaction and Cell-Mediated Immune Response Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model_state"
],
"from": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.state"
},
{
"to": [
"visualisation.immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model_summary"
],
"from": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model_species_labels"
],
"from": "immunology_sbml_lopez2014_a_validated_mathematical_model_of_tumo_biomd0000000784_model.species_labels"
}
],
"package": "lopez2014-a-validated-mathematical-model-of-tumor-growth",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a dynamical model of cancer growth that includes three interacting cell populations of tumor cells, healthy host cells and immune effector cells. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagelopez2014-a-validated-mathematical-model-of-tumor-growth
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother
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