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This is a spatially averaged multiscale mathematical model of tumor angiogenesis. The model describes the dynamics of VEGF, Ang1, Ang2, and PDGF, coupled with those of mature and immature endothelial.
Manifest
{
"io": {
"inputs": [
{
"name": "epsilon_source_parameter",
"label": "Epsilon source parameter",
"units": "native SBML value",
"default": 0.04,
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.epsilon_source_parameter",
"description": "Epsilon source parameter. Maps to bundled SBML parameter `epsilon`."
}
],
"outputs": [
{
"name": "v",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.v",
"description": "V observable. Maps to SBML symbol `v`."
},
{
"name": "rv",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.rv",
"description": "Rv observable. Maps to SBML symbol `rv`."
},
{
"name": "bv",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.bv",
"description": "Bv observable. Maps to SBML symbol `bv`."
},
{
"name": "a1",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.a1",
"description": "A1 observable. Maps to SBML symbol `a1`."
},
{
"name": "aw",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.aw",
"description": "Aw observable. Maps to SBML symbol `aw`."
},
{
"name": "a2",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.a2",
"description": "A2 observable. Maps to SBML symbol `a2`."
},
{
"name": "state",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"angiogenesis",
"biomodels_ebi",
"curated",
"drug-response",
"faithful",
"microenvironment",
"oncology",
"pharmacology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "Hutchinson2016 - Vascular phenotype identification and anti-angiogenic treatment recommendation Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model_state"
],
"from": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.state"
},
{
"to": [
"visualisation.oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model_summary"
],
"from": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model_species_labels"
],
"from": "oncology_sbml_hutchinson2016_vascular_phenotype_identification_model1911130007_model.species_labels"
}
],
"package": "hutchinson2016-vascular-phenotype-identification-and-an-1f3af325",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a spatially averaged multiscale mathematical model of tumor angiogenesis. The model describes the dynamics of VEGF, Ang1, Ang2, and PDGF, coupled with those of mature and immature endothelial.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagehutchinson2016-vascular-phenotype-identification-and-an-1f3af325
Created2026-05-16
Updated2026-06-13
angiogenesisbiomodels_ebicurateddrug-responsefaithfulmicroenvironmentoncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisationother