Telesco2011_HER3-ErbB3-RTK_SignalingNetwork Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_total_her3_receptor",
        "label": "Initial Total HER3 Receptor",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.initial_total_her3_receptor"
      },
      {
        "name": "initial_her3_neuregulin_complex",
        "label": "Initial HER3 Neuregulin Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.initial_her3_neuregulin_complex"
      },
      {
        "name": "initial_phosphorylated_her3_neuregulin_pi3k_complex",
        "label": "Initial Phosphorylated HER3 Neuregulin PI3K Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.initial_phosphorylated_her3_neuregulin_pi3k_complex"
      },
      {
        "name": "initial_internalized_phosphorylated_her3_pi3k_complex",
        "label": "Initial Internalized Phosphorylated HER3 PI3K Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.initial_internalized_phosphorylated_her3_pi3k_complex"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.species_labels"
      },
      {
        "name": "phosphorylated_her3_neuregulin_pi3k_complex",
        "label": "Phosphorylated HER3 Neuregulin PI3K Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.phosphorylated_her3_neuregulin_pi3k_complex"
      },
      {
        "name": "phosphorylated_her3_1_neuregulin_pi3k_complex",
        "label": "Phosphorylated HER3 1 Neuregulin PI3K Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.phosphorylated_her3_1_neuregulin_pi3k_complex"
      },
      {
        "name": "phosphorylated_her3_neuregulin_pi3k_pip2_complex",
        "label": "Phosphorylated HER3 Neuregulin PI3K PIP2 Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.phosphorylated_her3_neuregulin_pi3k_pip2_complex"
      },
      {
        "name": "internalized_phosphorylated_her3_neuregulin_pi3k_complex",
        "label": "Internalized Phosphorylated HER3 Neuregulin PI3K Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.internalized_phosphorylated_her3_neuregulin_pi3k_complex"
      },
      {
        "name": "internalized_phosphorylated_her3_neuregulin_pi3k_pip2_complex",
        "label": "Internalized Phosphorylated HER3 Neuregulin PI3K PIP2 Complex",
        "maps_to": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.internalized_phosphorylated_her3_neuregulin_pi3k_pip2_complex"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "signaling",
    "oncology",
    "receptor-tyrosine-kinase",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Telesco2011_HER3-ErbB3-RTK_SignalingNetwork Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model",
      "parameters": {
        "model_path": "data/MODEL1102210001.xml",
        "integration_step": 0.2
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model_state"
      ],
      "from": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model_summary"
      ],
      "from": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model_species_labels"
      ],
      "from": "pharmacology_sbml_telesco2011_her3_erbb3_rtk_signalingnetwork_model1102210001_model.species_labels"
    }
  ],
  "package": "telesco2011-her3-erbb3-rtk-signaling",
  "runtime": {
    "duration": 60,
    "initial_inputs": {},
    "communication_step": 2
  },
  "version": "1.0.0",
  "description": "This model is from the article: A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling n. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}