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SBML and SBGN-ML models of atherosclerosis and atheroma formation. This model is described in the publication: New models of atherosclerosis and multi-drug therapeutic interventions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_ldl",
"label": "Initial LDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_ldl"
},
{
"name": "initial_hdl",
"label": "Initial HDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_hdl"
},
{
"name": "initial_free_oxygen_radicals",
"label": "Initial Free Oxygen Radicals",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_free_oxygen_radicals"
},
{
"name": "initial_monocytes",
"label": "Initial Monocytes",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_monocytes"
},
{
"name": "initial_t_cells",
"label": "Initial T Cells",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.initial_t_cells"
}
],
"outputs": [
{
"name": "state",
"label": "Tracked source state",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.species_labels"
},
{
"name": "hdl",
"label": "HDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.hdl"
},
{
"name": "ldl",
"label": "LDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.ldl"
},
{
"name": "blood_ldl",
"label": "Blood LDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.blood_ldl"
},
{
"name": "blood_hdl",
"label": "Blood HDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.blood_hdl"
},
{
"name": "oxidized_ldl",
"label": "Oxidized LDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.oxidized_ldl"
},
{
"name": "oxidized_hdl",
"label": "Oxidized HDL",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.oxidized_hdl"
},
{
"name": "monocytes",
"label": "Monocytes",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.monocytes"
},
{
"name": "macrophages",
"label": "Macrophages",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.macrophages"
},
{
"name": "foam_cells",
"label": "Foam Cells",
"maps_to": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.foam_cells"
}
]
},
"tags": [
"pharmacology",
"cardiovascular",
"physiology",
"inflammation",
"systems-biology",
"sbml",
"tellurium",
"faithful",
"biomodels_ebi"
],
"title": "Parton2018 - A model of Atherosclerosis and atheroma formation. Lab",
"models": [
{
"path": "models/core",
"alias": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model",
"parameters": {
"model_path": "data/MODEL1812100001.xml",
"integration_step": 0.05
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model_state"
],
"from": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.state"
},
{
"to": [
"visualisation.pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model_summary"
],
"from": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.summary"
},
{
"to": [
"visualisation.pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model_species_labels"
],
"from": "pharmacology_sbml_parton2018_a_model_of_atherosclerosis_and_athero_model1812100001_model.species_labels"
}
],
"package": "parton2018-atherosclerosis-atheroma",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 0.5
},
"version": "1.0.0",
"description": "SBML and SBGN-ML models of atherosclerosis and atheroma formation. This model is described in the publication: New models of atherosclerosis and multi-drug therapeutic interventions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step0.5
Runs
Total0
Completed0
Failed0
Metadata
Packageparton2018-atherosclerosis-atheroma
Created2026-05-16
Updated2026-06-13
pharmacologycardiovascularphysiologyinflammationsystems-biologysbmltelluriumfaithfulbiomodels_ebivisualisationother