Eftimie2019 Macrophages Plasticity Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_virus_xv",
        "label": "Initial Virus Xv",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_virus_xv",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Virus_Xv`."
      },
      {
        "name": "initial_m2_macrophage_xm2",
        "label": "Initial M2 Macrophage XM2",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_m2_macrophage_xm2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M2_Macrophage_Xm2`."
      },
      {
        "name": "initial_m1_macrophage_xm1",
        "label": "Initial M1 Macrophage XM1",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_m1_macrophage_xm1",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M1_Macrophage_Xm1`."
      },
      {
        "name": "initial_infected_tumour_cells_xi",
        "label": "Initial Infected Tumour Cells Xi",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_infected_tumour_cells_xi",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Infected_Tumour_Cells_Xi`."
      },
      {
        "name": "initial_un_infected_tumour_cells_xu",
        "label": "Initial Un Infected Tumour Cells Xu",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_un_infected_tumour_cells_xu",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `UnInfected_Tumour_Cells_Xu`."
      },
      {
        "name": "initial_effector_cytotoxic_cd8_t_cells_xe",
        "label": "Initial Effector Cytotoxic CD8 T Cells Xe",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.initial_effector_cytotoxic_cd8_t_cells_xe",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Effector_Cytotoxic_CD8_TCells__Xe`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.species_labels"
      },
      {
        "name": "virus_xv",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.virus_xv"
      },
      {
        "name": "m2_macrophage_xm2",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.m2_macrophage_xm2"
      },
      {
        "name": "m1_macrophage_xm1",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.m1_macrophage_xm1"
      },
      {
        "name": "infected_tumour_cells_xi",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.infected_tumour_cells_xi"
      },
      {
        "name": "un_infected_tumour_cells_xu",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.un_infected_tumour_cells_xu"
      },
      {
        "name": "effector_cytotoxic_cd8_t_cells_xe",
        "maps_to": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.effector_cytotoxic_cd8_t_cells_xe"
      }
    ]
  },
  "tags": [
    "immunology",
    "oncology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Eftimie2019 Macrophages Plasticity Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model_state"
      ],
      "from": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model_summary"
      ],
      "from": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model_species_labels"
      ],
      "from": "systemsbiology_sbml_eftimie2019_macrophages_plasticity_biomd0000000806_model.species_labels"
    }
  ],
  "package": "eftimie2019-macrophages-plasticity",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "This paper describes the complex interactions between two extreme types of macrophages (M1 and M2 cells), effector T cells and an oncolytic Vesicular Stomatitis Virus (VSV), on the growth/elimination. It can be used to explore systemsbiology eftimie2019 macrophages plasticity BioModels0000000806 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}