Jarrah2014 - mathematical model of the immune response in muscle degeneration and subsequent regeneration in Duchenne muscular dystrophy in mdx mice Lab
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Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.The genetic defect responsible for DMD has been known for over 25 years, yet at pre. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cd4_t_helper_cells_h",
"label": "Initial CD4 T Helper Cells H",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_cd4_t_helper_cells_h",
"description": "Initial CD4 T Helper Cells H. Sets the initial value of bundled SBML species `H`."
},
{
"name": "initial_macrophages_m",
"label": "Initial Macrophages M",
"units": "substance",
"default": 400,
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_macrophages_m",
"description": "Initial Macrophages M. Sets the initial value of bundled SBML species `M`."
},
{
"name": "initial_cd8_cytotoxic_t_lymphocytes_c",
"label": "Initial CD8 Cytotoxic T Lymphocytes C",
"units": "substance",
"default": 4,
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_cd8_cytotoxic_t_lymphocytes_c",
"description": "Initial CD8 Cytotoxic T Lymphocytes C. Sets the initial value of bundled SBML species `C`."
},
{
"name": "initial_damaged_fibres_d",
"label": "Initial Damaged Fibres D",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_damaged_fibres_d",
"description": "Initial Damaged Fibres D. Sets the initial value of bundled SBML species `D`."
},
{
"name": "initial_normal_fibres_n",
"label": "Initial Normal Fibres N",
"units": "substance",
"default": 100,
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.initial_normal_fibres_n",
"description": "Initial Normal Fibres N. Sets the initial value of bundled SBML species `N`."
}
],
"outputs": [
{
"name": "cd4_t_helper_cells_h",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.cd4_t_helper_cells_h"
},
{
"name": "macrophages_m",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.macrophages_m"
},
{
"name": "cd8_cytotoxic_t_lymphocytes_c",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.cd8_cytotoxic_t_lymphocytes_c"
},
{
"name": "damaged_fibres_d",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.damaged_fibres_d"
},
{
"name": "normal_fibres_n",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.normal_fibres_n"
},
{
"name": "state",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.species_labels"
}
]
},
"title": "Jarrah2014 - mathematical model of the immune response in muscle degeneration and subsequent regeneration in Duchenne muscular dystrophy in mdx mice Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model_state"
],
"from": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.state"
},
{
"to": [
"visualisation.immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model_summary"
],
"from": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model_species_labels"
],
"from": "immunology_sbml_jarrah2014_mathematical_model_of_the_immune_resp_biomd0000001015_model.species_labels"
}
],
"package": "jarrah2014-mathematical-model-of-the-immune-response-in",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.The genetic defect responsible for DMD has been known for over 25 years, yet at pre. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagejarrah2014-mathematical-model-of-the-immune-response-in
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother