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Grange2001 - L-dopa PK model A pharmacokinetics of L-dopa in rats after administration of L-dopa alone (this model: BIOMD0000000321) or L-dopa combined with a peripheral AADC (amino-acid-decarboxylase. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "l_dopa_dose_per_kg_rat",
"label": "L Dopa Dose Per Kg Rat",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.l_dopa_dose_per_kg_rat"
},
{
"name": "l_dopa_clearance_rate",
"label": "L Dopa Clearance Rate",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.l_dopa_clearance_rate"
},
{
"name": "omd_clearance_rate",
"label": "Omd Clearance Rate",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.omd_clearance_rate"
}
],
"outputs": [
{
"name": "state",
"label": "Tracked source state",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.species_labels"
},
{
"name": "l_dopa_amount",
"label": "L Dopa Amount",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.l_dopa_amount"
},
{
"name": "l_dopa_concentration",
"label": "L Dopa Concentration",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.l_dopa_concentration"
},
{
"name": "three_omd_concentration",
"label": "Three Omd Concentration",
"maps_to": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.three_omd_concentration"
}
]
},
"tags": [
"pharmacology",
"pharmacokinetics",
"neuroscience",
"pbpk",
"sbml",
"tellurium",
"faithful",
"biomodels_ebi"
],
"title": "Grange2001 - L Dopa PK model Lab",
"models": [
{
"path": "models/core",
"alias": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model",
"parameters": {
"model_path": "data/BIOMD0000000321.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model_state"
],
"from": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.state"
},
{
"to": [
"visualisation.pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model_summary"
],
"from": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.summary"
},
{
"to": [
"visualisation.pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model_species_labels"
],
"from": "pharmacology_sbml_grange2001_l_dopa_pk_model_biomd0000000321_model.species_labels"
}
],
"package": "grange2001-ldopa-pk",
"runtime": {
"duration": 24,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Grange2001 - L-dopa PK model A pharmacokinetics of L-dopa in rats after administration of L-dopa alone (this model: BIOMD0000000321) or L-dopa combined with a peripheral AADC (amino-acid-decarboxylase. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
"schema_version": "2.0"
}Runtime
Duration24
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagegrange2001-ldopa-pk
Created2026-05-16
Updated2026-06-13
pharmacologypharmacokineticsneurosciencepbpksbmltelluriumfaithfulbiomodels_ebivisualisationother