Huang1996 - Ultrasensitivity Mitogen Activated Protein Kinase Cascade Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_activated_mapkkk",
        "label": "Initial Activated Mapkkk",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.initial_activated_mapkkk",
        "description": "Initial value for Activated Mapkkk. Maps to source symbol `mosstar`. Units: micromolar. Naming evidence: source metadata names `mosstar` as `activated MAPKKK`.",
        "accepted_units": [
          "micromolar"
        ]
      },
      {
        "name": "initial_activated_mapkkk_e2_complex",
        "label": "Initial Activated Mapkkk E2 Complex",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.initial_activated_mapkkk_e2_complex",
        "description": "Initial value for Activated Mapkkk E2 Complex. Maps to source symbol `mosstare2`. Units: micromolar. Naming evidence: source metadata names `mosstare2` as `activated MAPKKK-E2 complex`.",
        "accepted_units": [
          "micromolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.variable_labels"
      },
      {
        "name": "biphosphorylated_mapk",
        "label": "Biphosphorylated Mapk",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.biphosphorylated_mapk",
        "description": "Biphosphorylated Mapk. Maps to source symbol `mapkstarstar`. Units: micromolar. Naming evidence: source metadata names `mapkstarstar` as `biphosphorylated MAPK`."
      },
      {
        "name": "mapk",
        "label": "Mapk",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.mapk",
        "description": "Mapk. Maps to source symbol `mapk`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "phosphorylated_mapk",
        "label": "Phosphorylated Mapk",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.phosphorylated_mapk",
        "description": "Phosphorylated Mapk. Maps to source symbol `mapkstar`. Units: micromolar. Naming evidence: source metadata names `mapkstar` as `phosphorylated MAPK`."
      },
      {
        "name": "mapk_biphosphorylated_mapkk_complex",
        "label": "Mapk Biphosphorylated Mapkk Complex",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.mapk_biphosphorylated_mapkk_complex",
        "description": "Mapk Biphosphorylated Mapkk Complex. Maps to source symbol `mapkmekstarstar`. Units: micromolar. Naming evidence: source metadata names `mapkmekstarstar` as `MAPK-biphosphorylated MAPKK complex`."
      },
      {
        "name": "phosphorylated_mapk_biphosphorylated_mapkk_complex",
        "label": "Phosphorylated Mapk Biphosphorylated Mapkk Complex",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.phosphorylated_mapk_biphosphorylated_mapkk_complex",
        "description": "Phosphorylated Mapk Biphosphorylated Mapkk Complex. Maps to source symbol `mapkstarmekstarstar`. Units: micromolar. Naming evidence: source metadata names `mapkstarmekstarstar` as `phosphorylated MAPK-biphosphorylated MAPKK complex`."
      },
      {
        "name": "phosphorylated_mapk_mapk_phosphatase_complex",
        "label": "Phosphorylated Mapk Mapk Phosphatase Complex",
        "maps_to": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.phosphorylated_mapk_mapk_phosphatase_complex",
        "description": "Phosphorylated Mapk Mapk Phosphatase Complex. Maps to source symbol `mapkstarmapkpase`. Units: micromolar. Naming evidence: source metadata names `mapkstarmapkpase` as `phosphorylated MAPK-MAPK phosphatase complex`."
      }
    ]
  },
  "title": "Huang1996 - Ultrasensitivity Mitogen Activated Protein Kinase Cascade Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model",
      "parameters": {
        "model_path": "data/huang_ferrell_1996.cellml",
        "integration_step": 0.01
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_huang_ferrell_1996_huangferrell1996_model_state"
      ],
      "from": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_huang_ferrell_1996_huangferrell1996_model_summary"
      ],
      "from": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_huang_ferrell_1996_huangferrell1996_model_trajectory"
      ],
      "from": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_huang_ferrell_1996_huangferrell1996_model_variable_labels"
      ],
      "from": "physiology_cellml_huang_ferrell_1996_huangferrell1996_model.variable_labels"
    }
  ],
  "package": "huang1996-ultrasensitivity-mitogen-activated-protein-ki-d8314857",
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "version": "1.0.0",
  "description": "Source-faithful physiology lab for Huang, Ferrell, 1996. Public controls and outputs are mapped to real source symbols for signalling physiology.",
  "schema_version": "2.0"
}