Gerard2009 - An Integrated Mammalian Cell Cycle Model Lab

{
  "io": {
    "inputs": [
      {
        "name": "growth_factor",
        "label": "Growth factor",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.growth_factor",
        "description": "Controls Growth factor in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.growth_factor`."
      },
      {
        "name": "growth_factor_activation_rate",
        "label": "Growth factor activation rate",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.growth_factor_activation_rate",
        "description": "Controls Growth factor activation rate in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.growth_factor_activation_rate`."
      }
    ],
    "outputs": [
      {
        "name": "phosphorylated_rb",
        "label": "Phosphorylated Rb",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_rb",
        "description": "Tracks Phosphorylated Rb in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_rb`."
      },
      {
        "name": "singly_phosphorylated_rb",
        "label": "Singly phosphorylated Rb",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.singly_phosphorylated_rb",
        "description": "Tracks Singly phosphorylated Rb in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.singly_phosphorylated_rb`."
      },
      {
        "name": "hyperphosphorylated_rb",
        "label": "Hyperphosphorylated Rb",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.hyperphosphorylated_rb",
        "description": "Tracks Hyperphosphorylated Rb in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.hyperphosphorylated_rb`."
      },
      {
        "name": "e2f",
        "label": "E2F transcription factor",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.e2f",
        "description": "Tracks E2F transcription factor in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.e2f`."
      },
      {
        "name": "phosphorylated_e2f",
        "label": "Phosphorylated E2F",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_e2f",
        "description": "Tracks Phosphorylated E2F in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_e2f`."
      },
      {
        "name": "rb_e2f_complex",
        "label": "Rb-E2F complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.rb_e2f_complex",
        "description": "Tracks Rb-E2F complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.rb_e2f_complex`."
      },
      {
        "name": "phosphorylated_rb_e2f_complex",
        "label": "Phosphorylated Rb-E2F complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_rb_e2f_complex",
        "description": "Tracks Phosphorylated Rb-E2F complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_rb_e2f_complex`."
      },
      {
        "name": "cyclin_d",
        "label": "Cyclin D",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_d",
        "description": "Tracks Cyclin D in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_d`."
      },
      {
        "name": "inactive_cyclin_d_cdk_complex",
        "label": "Inactive Cyclin D-CDK4/6 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_d_cdk_complex",
        "description": "Tracks Inactive Cyclin D-CDK4/6 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_d_cdk_complex`."
      },
      {
        "name": "active_cyclin_d_cdk_complex",
        "label": "Active Cyclin D-CDK4/6 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_d_cdk_complex",
        "description": "Tracks Active Cyclin D-CDK4/6 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_d_cdk_complex`."
      },
      {
        "name": "cyclin_d_cdk_p27_complex",
        "label": "Cyclin D-CDK4/6-p27 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_d_cdk_p27_complex",
        "description": "Tracks Cyclin D-CDK4/6-p27 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_d_cdk_p27_complex`."
      },
      {
        "name": "cyclin_e",
        "label": "Cyclin E",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_e",
        "description": "Tracks Cyclin E in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_e`."
      },
      {
        "name": "inactive_cyclin_e_cdk2_complex",
        "label": "Inactive Cyclin E-CDK2 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_e_cdk2_complex",
        "description": "Tracks Inactive Cyclin E-CDK2 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_e_cdk2_complex`."
      },
      {
        "name": "active_cyclin_e_cdk2_complex",
        "label": "Active Cyclin E-CDK2 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_e_cdk2_complex",
        "description": "Tracks Active Cyclin E-CDK2 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_e_cdk2_complex`."
      },
      {
        "name": "skp2",
        "label": "Skp2 ubiquitin-ligase adaptor",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.skp2",
        "description": "Tracks Skp2 ubiquitin-ligase adaptor in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.skp2`."
      },
      {
        "name": "cyclin_e_cdk2_p27_complex",
        "label": "Cyclin E-CDK2-p27 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_e_cdk2_p27_complex",
        "description": "Tracks Cyclin E-CDK2-p27 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_e_cdk2_p27_complex`."
      },
      {
        "name": "inactive_cyclin_e_module_regulator",
        "label": "Inactive Cyclin E module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_e_module_regulator",
        "description": "Tracks Inactive Cyclin E module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_e_module_regulator`."
      },
      {
        "name": "active_cyclin_e_module_regulator",
        "label": "Active Cyclin E module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_e_module_regulator",
        "description": "Tracks Active Cyclin E module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_e_module_regulator`."
      },
      {
        "name": "cyclin_a",
        "label": "Cyclin A",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_a",
        "description": "Tracks Cyclin A in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_a`."
      },
      {
        "name": "inactive_cyclin_a_cdk2_complex",
        "label": "Inactive Cyclin A-CDK2 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_a_cdk2_complex",
        "description": "Tracks Inactive Cyclin A-CDK2 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_a_cdk2_complex`."
      },
      {
        "name": "active_cyclin_a_cdk2_complex",
        "label": "Active Cyclin A-CDK2 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_a_cdk2_complex",
        "description": "Tracks Active Cyclin A-CDK2 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_a_cdk2_complex`."
      },
      {
        "name": "cyclin_a_cdk2_p27_complex",
        "label": "Cyclin A-CDK2-p27 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_a_cdk2_p27_complex",
        "description": "Tracks Cyclin A-CDK2-p27 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_a_cdk2_p27_complex`."
      },
      {
        "name": "p27",
        "label": "p27 CDK inhibitor",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.p27",
        "description": "Tracks p27 CDK inhibitor in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.p27`."
      },
      {
        "name": "phosphorylated_p27",
        "label": "Phosphorylated p27",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_p27",
        "description": "Tracks Phosphorylated p27 in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_p27`."
      },
      {
        "name": "inactive_cdh1",
        "label": "Inactive Cdh1",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cdh1",
        "description": "Tracks Inactive Cdh1 in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cdh1`."
      },
      {
        "name": "active_cdh1",
        "label": "Active Cdh1",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cdh1",
        "description": "Tracks Active Cdh1 in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cdh1`."
      },
      {
        "name": "inactive_cyclin_a_module_regulator",
        "label": "Inactive Cyclin A module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_a_module_regulator",
        "description": "Tracks Inactive Cyclin A module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_a_module_regulator`."
      },
      {
        "name": "active_cyclin_a_module_regulator",
        "label": "Active Cyclin A module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_a_module_regulator",
        "description": "Tracks Active Cyclin A module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_a_module_regulator`."
      },
      {
        "name": "cyclin_b",
        "label": "Cyclin B",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_b",
        "description": "Tracks Cyclin B in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_b`."
      },
      {
        "name": "inactive_cyclin_b_cdk1_complex",
        "label": "Inactive Cyclin B-CDK1 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_b_cdk1_complex",
        "description": "Tracks Inactive Cyclin B-CDK1 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_b_cdk1_complex`."
      },
      {
        "name": "active_cyclin_b_cdk1_complex",
        "label": "Active Cyclin B-CDK1 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_b_cdk1_complex",
        "description": "Tracks Active Cyclin B-CDK1 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_b_cdk1_complex`."
      },
      {
        "name": "cyclin_b_cdk1_p27_complex",
        "label": "Cyclin B-CDK1-p27 complex",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_b_cdk1_p27_complex",
        "description": "Tracks Cyclin B-CDK1-p27 complex in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cyclin_b_cdk1_p27_complex`."
      },
      {
        "name": "inactive_cdc20",
        "label": "Inactive Cdc20",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cdc20",
        "description": "Tracks Inactive Cdc20 in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cdc20`."
      },
      {
        "name": "active_cdc20",
        "label": "Active Cdc20",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cdc20",
        "description": "Tracks Active Cdc20 in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cdc20`."
      },
      {
        "name": "inactive_cyclin_b_module_regulator",
        "label": "Inactive Cyclin B module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_b_module_regulator",
        "description": "Tracks Inactive Cyclin B module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.inactive_cyclin_b_module_regulator`."
      },
      {
        "name": "active_cyclin_b_module_regulator",
        "label": "Active Cyclin B module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_b_module_regulator",
        "description": "Tracks Active Cyclin B module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.active_cyclin_b_module_regulator`."
      },
      {
        "name": "wee1",
        "label": "Wee1 inhibitory kinase",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.wee1",
        "description": "Tracks Wee1 inhibitory kinase in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.wee1`."
      },
      {
        "name": "phosphorylated_wee1",
        "label": "Phosphorylated Wee1",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_wee1",
        "description": "Tracks Phosphorylated Wee1 in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.phosphorylated_wee1`."
      },
      {
        "name": "dna_polymerase",
        "label": "DNA polymerase",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.dna_polymerase",
        "description": "Tracks DNA polymerase in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.dna_polymerase`."
      },
      {
        "name": "cdc45",
        "label": "Cdc45 replication factor",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cdc45",
        "description": "Tracks Cdc45 replication factor in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.cdc45`."
      },
      {
        "name": "replication_primer",
        "label": "Replication primer",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.replication_primer",
        "description": "Tracks Replication primer in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.replication_primer`."
      },
      {
        "name": "chk1",
        "label": "Chk1 checkpoint kinase",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.chk1",
        "description": "Tracks Chk1 checkpoint kinase in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.chk1`."
      },
      {
        "name": "atr",
        "label": "ATR checkpoint kinase",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.atr",
        "description": "Tracks ATR checkpoint kinase in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.atr`."
      },
      {
        "name": "ap1",
        "label": "AP1 transcription factor",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.ap1",
        "description": "Tracks AP1 transcription factor in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.ap1`."
      },
      {
        "name": "wee1_module_regulator",
        "label": "Wee1 module regulator",
        "maps_to": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.wee1_module_regulator",
        "description": "Tracks Wee1 module regulator in the lab model via `cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.wee1_module_regulator`."
      }
    ]
  },
  "title": "Gerard2009 - An Integrated Mammalian Cell Cycle Model Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model_state"
      ],
      "from": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model_summary"
      ],
      "from": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model_species_labels"
      ],
      "from": "cellcycle_sbml_gerard2009_an_integrated_mammalian_cell_cycle_mo_biomd0000000730_model.species_labels"
    }
  ],
  "package": "gerard2009-integrated-mammalian-cell-cycle",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Single-model lab wrapper for Gerard2009 - An Integrated Mammalian Cell Cycle Model. We propose an integrated computational model for the network of cyclin-dependent kinases (Cdks) that controls the dynamics of the mammalian cell cycle. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}