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The paper describes a model of glioblastoma. Created by COPASI 4.25 (Build 207) This model is described in the article: Modeling the Treatment of Glioblastoma Multiforme and Cancer Stem Cells with Ord.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tumor_burden",
"label": "Tumor",
"units": "native SBML value",
"default": 70,
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.initial_tumor_burden",
"description": "Initial Tumor. Sets the initial value of bundled SBML symbol `Tumor`."
},
{
"name": "initial_cancer_stem_cells",
"label": "CancerStemCell",
"units": "native SBML value",
"default": 30,
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.initial_cancer_stem_cells",
"description": "Initial CancerStemCell. Sets the initial value of bundled SBML symbol `CancerStemCell`."
},
{
"name": "initial_cytotoxic_t_cells",
"label": "CytotoxicTcell",
"units": "native SBML value",
"default": 250,
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.initial_cytotoxic_t_cells",
"description": "Initial CytotoxicTcell. Sets the initial value of bundled SBML symbol `CytotoxicTcell`."
},
{
"name": "initial_tgf_beta",
"label": "TGFb",
"units": "native SBML value",
"default": 50,
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.initial_tgf_beta",
"description": "Initial TGFb. Sets the initial value of bundled SBML symbol `TGFb`."
},
{
"name": "initial_ifn_gamma",
"label": "IFNy",
"units": "native SBML value",
"default": 50,
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.initial_ifn_gamma",
"description": "Initial IFNy. Sets the initial value of bundled SBML symbol `IFNy`."
},
{
"name": "initial_mhc_i",
"label": "MHC1",
"units": "native SBML value",
"default": 50,
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.initial_mhc_i",
"description": "Initial MHC1. Sets the initial value of bundled SBML symbol `MHC1`."
}
],
"outputs": [
{
"name": "tumor_burden",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.tumor_burden",
"description": "Tumor observable. Maps to SBML symbol `Tumor`."
},
{
"name": "cancer_stem_cells",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.cancer_stem_cells",
"description": "CancerStemCell observable. Maps to SBML symbol `CancerStemCell`."
},
{
"name": "cytotoxic_t_cells",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.cytotoxic_t_cells",
"description": "CytotoxicTcell observable. Maps to SBML symbol `CytotoxicTcell`."
},
{
"name": "tgf_beta",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.tgf_beta",
"description": "TGFb observable. Maps to SBML symbol `TGFb`."
},
{
"name": "ifn_gamma",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.ifn_gamma",
"description": "IFNy observable. Maps to SBML symbol `IFNy`."
},
{
"name": "mhc_i",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.mhc_i",
"description": "MHC1 observable. Maps to SBML symbol `MHC1`."
},
{
"name": "state",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"biomodels_ebi",
"curated",
"drug-response",
"faithful",
"oncology",
"pharmacology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "Abernathy2016 - glioblastoma treatment Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model_state"
],
"from": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.state"
},
{
"to": [
"visualisation.oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model_summary"
],
"from": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model_species_labels"
],
"from": "oncology_sbml_abernathy2016_glioblastoma_treatment_biomd0000000757_model.species_labels"
}
],
"package": "abernathy2016-glioblastoma-treatment",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "The paper describes a model of glioblastoma. Created by COPASI 4.25 (Build 207) This model is described in the article: Modeling the Treatment of Glioblastoma Multiforme and Cancer Stem Cells with Ord.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageabernathy2016-glioblastoma-treatment
Created2026-05-16
Updated2026-06-13
biomodels_ebicurateddrug-responsefaithfuloncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisationother