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NF-kB/IkB knockout signaling. The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species th.
Manifest
{
"io": {
"inputs": [],
"outputs": [
{
"name": "nfkb",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.nfkb"
},
{
"name": "ikb_alpha",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha"
},
{
"name": "ikk",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.ikk"
},
{
"name": "ikb_alpha_nfkb_complex",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha_nfkb_complex"
},
{
"name": "state",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.state"
},
{
"name": "summary",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.summary"
},
{
"name": "species_labels",
"maps_to": "hoffmann2002_nfkb_ikb_knockout.species_labels"
}
]
},
"title": "Hoffmann2002 Nfkb Ikb Knockout Lab",
"models": [
{
"path": "models/core",
"alias": "hoffmann2002_nfkb_ikb_knockout",
"parameters": {
"model_path": "data/BIOMD0000000139.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_nfkb"
],
"from": "hoffmann2002_nfkb_ikb_knockout.nfkb"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_ikb_alpha"
],
"from": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_ikk"
],
"from": "hoffmann2002_nfkb_ikb_knockout.ikk"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_ikb_alpha_nfkb_complex"
],
"from": "hoffmann2002_nfkb_ikb_knockout.ikb_alpha_nfkb_complex"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_state"
],
"from": "hoffmann2002_nfkb_ikb_knockout.state"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_summary"
],
"from": "hoffmann2002_nfkb_ikb_knockout.summary"
},
{
"to": [
"visualisation.hoffmann2002_nfkb_ikb_knockout_species_labels"
],
"from": "hoffmann2002_nfkb_ikb_knockout.species_labels"
}
],
"package": "hoffmann2002-nfkb-ikb-knockout",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "NF-kB/IkB knockout signaling. The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species th.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagehoffmann2002-nfkb-ikb-knockout
Created2026-05-15
Updated2026-06-13
generegulationsbmlbiomodels_ebifaithfulvisualisationother