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Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_signaling_observable_1",
"label": "Initial Unresolved Signaling Observable 1",
"units": "native source value",
"default": 1e-10,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_unresolved_signaling_observable_1",
"description": "Initial Unresolved Signaling Observable 1. Sets the initial value of bundled SBML species `S1`."
},
{
"name": "initial_dna_000",
"label": "Initial DNA 000",
"units": "native source value",
"default": 1e-10,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_000",
"description": "Initial DNA 000. Sets the initial value of bundled SBML species `DNA_000`."
},
{
"name": "initial_dna_100",
"label": "Initial DNA 100",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_100",
"description": "Initial DNA 100. Sets the initial value of bundled SBML species `DNA_100`."
},
{
"name": "initial_dna_010",
"label": "Initial DNA 010",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_010",
"description": "Initial DNA 010. Sets the initial value of bundled SBML species `DNA_010`."
},
{
"name": "initial_dna_001",
"label": "Initial DNA 001",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.initial_dna_001",
"description": "Initial DNA 001. Sets the initial value of bundled SBML species `DNA_001`."
}
],
"outputs": [
{
"name": "unresolved_signaling_observable_1",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.unresolved_signaling_observable_1"
},
{
"name": "dna_000",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_000"
},
{
"name": "dna_100",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_100"
},
{
"name": "dna_010",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_010"
},
{
"name": "dna_001",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.dna_001"
},
{
"name": "state",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.species_labels"
}
]
},
"title": "Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model_state"
],
"from": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.state"
},
{
"to": [
"visualisation.immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model_summary"
],
"from": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model_species_labels"
],
"from": "immunology_sbml_begitt2014_stat1_cooperative_dna_binding_single_biomd0000000500_model.species_labels"
}
],
"package": "begitt2014-stat1-cooperative-dna-binding-single-gas-polymer",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagebegitt2014-stat1-cooperative-dna-binding-single-gas-polymer
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother