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This a model from the article: A role for calcium release-activated current (CRAC) in cholinergic modulation ofelectrical activity in pancreatic beta-cells. It can be used to explore systemsbiology bertram1995 pancreaticbetacell crac BioModels0000000374 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_v_membrane",
"label": "Initial V Membrane",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.initial_v_membrane",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `V_membrane`."
},
{
"name": "initial_ca_er_ca_equations",
"label": "Initial Ca Er Ca Equations",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.initial_ca_er_ca_equations",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_er_Ca_equations`."
},
{
"name": "initial_model_state_jm",
"label": "Initial Model State Jm",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.initial_model_state_jm",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `jm`."
},
{
"name": "initial_ca_i",
"label": "Initial Ca I",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.initial_ca_i",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca_i`."
},
{
"name": "initial_model_state_n",
"label": "Initial Model State N",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.initial_model_state_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `n`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.species_labels"
},
{
"name": "v_membrane",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.v_membrane"
},
{
"name": "ca_er_ca_equations",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.ca_er_ca_equations"
},
{
"name": "model_state_jm",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.model_state_jm"
},
{
"name": "ca_i",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.ca_i"
},
{
"name": "model_state_n",
"maps_to": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.model_state_n"
}
]
},
"tags": [
"physiology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Bertram1995 Pancreaticbetacell Crac Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model_state"
],
"from": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model_summary"
],
"from": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model_species_labels"
],
"from": "systemsbiology_sbml_bertram1995_pancreaticbetacell_crac_biomd0000000374_model.species_labels"
}
],
"package": "bertram1995-pancreaticbetacell-crac",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This a model from the article: A role for calcium release-activated current (CRAC) in cholinergic modulation ofelectrical activity in pancreatic beta-cells. It can be used to explore systemsbiology bertram1995 pancreaticbetacell crac BioModels0000000374 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagebertram1995-pancreaticbetacell-crac
Created2026-05-17
Updated2026-06-13
physiologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother