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A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). It can be used to explore systemsbiology mclean1991 behaviour of hiv in dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_r",
"label": "Initial Model State R",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.initial_model_state_r",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `R`."
},
{
"name": "initial_model_state_v",
"label": "Initial Model State V",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.initial_model_state_v",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `V`."
},
{
"name": "initial_model_state_l",
"label": "Initial Model State L",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.initial_model_state_l",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `L`."
},
{
"name": "initial_model_state_e",
"label": "Initial Model State E",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.initial_model_state_e",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `E`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.species_labels"
},
{
"name": "model_state_r",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.model_state_r"
},
{
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},
{
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"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.model_state_l"
},
{
"name": "model_state_e",
"maps_to": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.model_state_e"
}
]
},
"tags": [
"epidemiology",
"pharmacology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Mclean1991 Behaviour Of Hiv In The Presence Of Zidovudine Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
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],
"from": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.state"
},
{
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],
"from": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.summary"
},
{
"to": [
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],
"from": "systemsbiology_sbml_mclean1991_behaviour_of_hiv_in_the_presence_of_z_biomd0000000967_model.species_labels"
}
],
"package": "mclean1991-behaviour-of-hiv-in-the-presence-of-zidovudine",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "A new mechanism is proposed for the apparent breakthrough of HIV that occurs approximately 6 months after the commencement of therapy with zidovudine (AZT). It can be used to explore systemsbiology mclean1991 behaviour of hiv in dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagemclean1991-behaviour-of-hiv-in-the-presence-of-zidovudine
Created2026-05-17
Updated2026-06-13
epidemiologypharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother