Kessler2025 - IL-6 and IL-22 pathway in human hepatocytes Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_il6rc_dimer_shp2",
        "label": "Initial IL6RC Dimer SHP2",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.initial_il6rc_dimer_shp2",
        "description": "Initial level of IL6RC Dimer SHP2. Maps to SBML symbol `P0`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "stat3",
        "label": "STAT3",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.stat3",
        "description": "STAT3. Maps to SBML symbol `P8` and is emitted in native SBML units."
      },
      {
        "name": "stat1",
        "label": "STAT1",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.stat1",
        "description": "STAT1. Maps to SBML symbol `P9` and is emitted in native SBML units."
      },
      {
        "name": "il6rc_dimer_stat1",
        "label": "IL6RC Dimer STAT1",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.il6rc_dimer_stat1",
        "description": "IL6RC Dimer STAT1. Maps to SBML symbol `P11` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "cytokine-signaling",
    "interleukin-signaling"
  ],
  "title": "Kessler2025 - IL-6 and IL-22 pathway in human hepatocytes Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model_state"
      ],
      "from": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model_summary"
      ],
      "from": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model_species_labels"
      ],
      "from": "signaling_sbml_kessler2025_il_6_and_il_22_pathway_in_human_hepa_model2509100001_model.species_labels"
    }
  ],
  "package": "kessler2025-il-6-and-il-22-pathway-in-human-hepa",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "Clean Biosimulant lab for systems signaling model: Kessler2025 - IL-6 and IL-22 pathway in human hepatocytes. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}