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This a model from the article: Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_adp",
"units": "native SBML value",
"default": 4.9,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_adp",
"description": "Initial condition for adp. Maps to bundled SBML symbol `ADP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_nad",
"units": "native SBML value",
"default": 6.33,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_nad",
"description": "Initial condition for nad. Maps to bundled SBML symbol `NAD`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_atp",
"units": "native SBML value",
"default": 0.1,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_atp",
"description": "Initial condition for atp. Maps to bundled SBML symbol `ATP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_nadh",
"units": "native SBML value",
"default": 3.67,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_nadh",
"description": "Initial condition for nadh. Maps to bundled SBML symbol `NADH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_5",
"units": "native SBML value",
"default": 1,
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.initial_metabolic_pathway_state_5",
"description": "Initial condition for metabolic pathway state 5. Maps to bundled SBML symbol `pyruvate`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
}
],
"outputs": [
{
"name": "adp",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.adp"
},
{
"name": "nad",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.nad"
},
{
"name": "atp",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.atp"
},
{
"name": "nadh",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.nadh"
},
{
"name": "metabolic_pathway_state_5",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.metabolic_pathway_state_5"
},
{
"name": "observable_values",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_values"
},
{
"name": "run_summary",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.run_summary"
},
{
"name": "observable_labels",
"maps_to": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_labels"
}
]
},
"title": "Hoefnagel2002_PyruvateBranches Lab",
"models": [
{
"path": "models/core",
"alias": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model",
"parameters": {
"model_path": "data/BIOMD0000000017.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model_observable_values"
],
"from": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_values"
},
{
"to": [
"visualisation.metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model_run_summary"
],
"from": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.run_summary"
},
{
"to": [
"visualisation.metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model_observable_labels"
],
"from": "metabolism_sbml_hoefnagel2002_pyruvatebranches_biomd0000000017_model.observable_labels"
}
],
"package": "hoefnagel2002-pyruvatebranches",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This a model from the article: Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagehoefnagel2002-pyruvatebranches
Created2026-05-15
Updated2026-06-13
biomodels_ebifaithfulmetabolismodesbmltelluriumvisualisationother