Zager2007 - Schlosser Tran Delayed Nonlinear PBPK Genistein Dosimetry Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_amount_of_genistein_conjugates_in_bile_delayed_compartment",
        "label": "Initial Amount Of Genistein Conjugates In Bile Delayed Compartment",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.initial_amount_of_genistein_conjugates_in_bile_delayed_compartment",
        "description": "Initial value for Amount Of Genistein Conjugates In Bile Delayed Compartment. Maps to source symbol `Acon_b`. Units: micromole. Naming evidence: source metadata names `Acon_b` as `amount of genistein conjugates in bile-delayed compartment`.",
        "accepted_units": [
          "micromole"
        ]
      },
      {
        "name": "initial_concentration_of_genistein_conjugates_in_liver",
        "label": "Initial Concentration Of Genistein Conjugates In Liver",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.initial_concentration_of_genistein_conjugates_in_liver",
        "description": "Initial value for Concentration Of Genistein Conjugates In Liver. Maps to source symbol `Ccon_l`. Units: micromolar. Naming evidence: source metadata names `Ccon_l` as `concentration of genistein conjugates in liver`.",
        "accepted_units": [
          "micromolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.variable_labels"
      },
      {
        "name": "amount_of_genistein_conjugates_in_bile_delayed_compartment",
        "label": "Amount Of Genistein Conjugates In Bile Delayed Compartment",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.amount_of_genistein_conjugates_in_bile_delayed_compartment",
        "description": "Amount Of Genistein Conjugates In Bile Delayed Compartment. Maps to source symbol `Acon_b`. Units: micromole. Naming evidence: source metadata names `Acon_b` as `amount of genistein conjugates in bile-delayed compartment`."
      },
      {
        "name": "concentration_of_genistein_conjugates_in_liver",
        "label": "Concentration Of Genistein Conjugates In Liver",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.concentration_of_genistein_conjugates_in_liver",
        "description": "Concentration Of Genistein Conjugates In Liver. Maps to source symbol `Ccon_l`. Units: micromolar. Naming evidence: source metadata names `Ccon_l` as `concentration of genistein conjugates in liver`."
      },
      {
        "name": "concentration_of_genistein_conjugates_in_rest_of_body",
        "label": "Concentration Of Genistein Conjugates In Rest Of Body",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.concentration_of_genistein_conjugates_in_rest_of_body",
        "description": "Concentration Of Genistein Conjugates In Rest Of Body. Maps to source symbol `Ccon_ROB`. Units: micromolar. Naming evidence: source metadata names `Ccon_ROB` as `concentration of genistein conjugates in rest-of-body`."
      },
      {
        "name": "concentration_of_pure_genistein_in_gastrointestinal_tract_lumen",
        "label": "Concentration Of Pure Genistein In Gastrointestinal Tract Lumen",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.concentration_of_pure_genistein_in_gastrointestinal_tract_lumen",
        "description": "Concentration Of Pure Genistein In Gastrointestinal Tract Lumen. Maps to source symbol `Cgen_GI`. Units: micromolar. Naming evidence: source metadata names `Cgen_GI` as `concentration of pure genistein in gastrointestinal tract lumen`."
      },
      {
        "name": "concentration_of_pure_genistein_in_liver",
        "label": "Concentration Of Pure Genistein In Liver",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.concentration_of_pure_genistein_in_liver",
        "description": "Concentration Of Pure Genistein In Liver. Maps to source symbol `Cgen_l`. Units: micromolar. Naming evidence: source metadata names `Cgen_l` as `concentration of pure genistein in liver`."
      },
      {
        "name": "concentration_of_pure_genistein_in_poorly_perfused_tissues",
        "label": "Concentration Of Pure Genistein In Poorly Perfused Tissues",
        "maps_to": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.concentration_of_pure_genistein_in_poorly_perfused_tissues",
        "description": "Concentration Of Pure Genistein In Poorly Perfused Tissues. Maps to source symbol `Cgen_pp`. Units: micromolar. Naming evidence: source metadata names `Cgen_pp` as `concentration of pure genistein in poorly perfused tissues`."
      }
    ]
  },
  "title": "Zager2007 - Schlosser Tran Delayed Nonlinear PBPK Genistein Dosimetry Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model",
      "parameters": {
        "model_path": "data/zager_schlosser_tran_2007.cellml",
        "integration_step": 0.01
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model_state"
      ],
      "from": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model_summary"
      ],
      "from": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model_trajectory"
      ],
      "from": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model_variable_labels"
      ],
      "from": "physiology_cellml_zager_schlosser_tran_2007_zagerschlossertran2007_model.variable_labels"
    }
  ],
  "package": "zager2007-schlosser-tran-delayed-nonlinear-pbpk-geniste-2b16c07e",
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "version": "1.0.0",
  "description": "Source-faithful physiology lab for Zager, Schlosser, Tran, 2007. Public controls and outputs are mapped to real source symbols for pharmacokinetics.",
  "schema_version": "2.0"
}