Bulik2016 - Regulation of hepatic glucose metabolism Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_extracellular_glucose",
        "units": "native SBML value",
        "default": 4,
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.initial_extracellular_glucose",
        "description": "Initial condition for extracellular glucose. Maps to bundled SBML symbol `glc_ext`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_extracellular_lactate",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.initial_extracellular_lactate",
        "description": "Initial condition for extracellular lactate. Maps to bundled SBML symbol `lac_ext`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_glucose",
        "units": "native SBML value",
        "default": 4.92256221964406,
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.initial_glucose",
        "description": "Initial condition for glucose. Maps to bundled SBML symbol `glc`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_glycolysis_state_4",
        "units": "native SBML value",
        "default": 0.189929897759633,
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.initial_glycolysis_state_4",
        "description": "Initial condition for glycolysis state 4. Maps to bundled SBML symbol `glc6p`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_glycolysis_state_5",
        "units": "native SBML value",
        "default": 0.0117240677629403,
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.initial_glycolysis_state_5",
        "description": "Initial condition for glycolysis state 5. Maps to bundled SBML symbol `glc1p`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "extracellular_glucose",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.extracellular_glucose"
      },
      {
        "name": "extracellular_lactate",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.extracellular_lactate"
      },
      {
        "name": "glucose",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.glucose"
      },
      {
        "name": "glycolysis_state_4",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.glycolysis_state_4"
      },
      {
        "name": "glycolysis_state_5",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.glycolysis_state_5"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.observable_labels"
      }
    ]
  },
  "title": "Bulik2016 - Regulation of hepatic glucose metabolism Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model",
      "parameters": {
        "model_path": "data/BIOMD0000000633.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model_observable_values"
      ],
      "from": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model_run_summary"
      ],
      "from": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model_observable_labels"
      ],
      "from": "metabolism_sbml_bulik2016_regulation_of_hepatic_glucose_metaboli_biomd0000000633_model.observable_labels"
    }
  ],
  "package": "bulik2016-regulation-of-hepatic-glucose-metabolism",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Bulik2016 - Regulation of hepatic glucosemetabolism This model is described in the article: The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic g. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}