Aavani2019 - The role of CD4 T cells in immune system activation and viral reproduction in a simple model for HIV infection Lab
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This is a mathematical model comprised of a simple system of four ordinary differential equations that account for the two opposing roles of infected and healthy cytotoxic T lymphocytes within the con. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_uninfected_cd4_t_cells",
"label": "Initial Uninfected CD4 T Cells",
"units": "native source value",
"default": 1000,
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_uninfected_cd4_t_cells",
"description": "Initial Uninfected CD4 T Cells. Sets the initial value of bundled SBML species `C_Uninfected_CD4`."
},
{
"name": "initial_infected_cd4_t_cells",
"label": "Initial Infected CD4 T Cells",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_infected_cd4_t_cells",
"description": "Initial Infected CD4 T Cells. Sets the initial value of bundled SBML species `I_Infected_CD4`."
},
{
"name": "initial_virus",
"label": "Initial Virus",
"units": "native source value",
"default": 200,
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_virus",
"description": "Initial Virus. Sets the initial value of bundled SBML species `V_Virus`."
},
{
"name": "initial_cytotoxic_t_lymphocytes",
"label": "Initial Cytotoxic T Lymphocytes",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.initial_cytotoxic_t_lymphocytes",
"description": "Initial Cytotoxic T Lymphocytes. Sets the initial value of bundled SBML species `F_CTL`."
},
{
"name": "cd4_uninfected_infection_rate",
"label": "CD4 Uninfected Infection Rate",
"units": "native source value",
"default": 0.0000575,
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.cd4_uninfected_infection_rate",
"description": "CD4 Uninfected Infection Rate. Sets bundled SBML parameter `beta`."
}
],
"outputs": [
{
"name": "uninfected_cd4_t_cells",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.uninfected_cd4_t_cells"
},
{
"name": "infected_cd4_t_cells",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.infected_cd4_t_cells"
},
{
"name": "virus",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.virus"
},
{
"name": "cytotoxic_t_lymphocytes",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.cytotoxic_t_lymphocytes"
},
{
"name": "state",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.species_labels"
}
]
},
"title": "Aavani2019 - The role of CD4 T cells in immune system activation and viral reproduction in a simple model for HIV infection Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model_state"
],
"from": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.state"
},
{
"to": [
"visualisation.immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model_summary"
],
"from": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model_species_labels"
],
"from": "immunology_sbml_aavani2019_the_role_of_cd4_t_cells_in_immune_sys_biomd0000000876_model.species_labels"
}
],
"package": "aavani2019-the-role-of-cd4-t-cells-in",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "This is a mathematical model comprised of a simple system of four ordinary differential equations that account for the two opposing roles of infected and healthy cytotoxic T lymphocytes within the con. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageaavani2019-the-role-of-cd4-t-cells-in
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother