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ABSTRACT: Intervertebral disc degeneration (IDD) arises from an intricate imbalance between the anabolic and catabolic processes governing the extracellular matrix (ECM) within the disc. It can be used to explore systemsbiology stseranidou2024 nucleus pulposus cell network dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_tnf",
"label": "Initial Model State TNF",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.initial_model_state_tnf",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TNF`."
},
{
"name": "initial_il_10",
"label": "Initial Il 10",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.initial_il_10",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IL_10`."
},
{
"name": "initial_il_1",
"label": "Initial Il 1",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.initial_il_1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IL_1beta`."
},
{
"name": "initial_model_state_tgf",
"label": "Initial Model State Tgf",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.initial_model_state_tgf",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TGF_beta`."
},
{
"name": "initial_il_8",
"label": "Initial Il 8",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.initial_il_8",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IL_8`."
},
{
"name": "initial_il_6",
"label": "Initial Il 6",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.initial_il_6",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IL_6`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.species_labels"
},
{
"name": "tnf",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.tnf"
},
{
"name": "il_10",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.il_10"
},
{
"name": "il_1",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.il_1"
},
{
"name": "tgf",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.tgf"
},
{
"name": "il_8",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.il_8"
},
{
"name": "il_6",
"maps_to": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.il_6"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Stseranidou2024 Nucleus Pulposus Cell Network Modelling In The Interverteb Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model_state"
],
"from": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model_summary"
],
"from": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model_species_labels"
],
"from": "systemsbiology_sbml_stseranidou2024_nucleus_pulposus_cell_network_mo_model2407080001_model.species_labels"
}
],
"package": "stseranidou2024-nucleus-pulposus-cell-network-modelling-4c37dcbe",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "ABSTRACT: Intervertebral disc degeneration (IDD) arises from an intricate imbalance between the anabolic and catabolic processes governing the extracellular matrix (ECM) within the disc. It can be used to explore systemsbiology stseranidou2024 nucleus pulposus cell network dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagestseranidou2024-nucleus-pulposus-cell-network-modelling-4c37dcbe
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother