Nazari2018 - IL6 mediated stem cell driven tumor growth and targeted treatment Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_progenitor_tumor_cell_e",
        "label": "Progenitor tumor cell E",
        "units": "native SBML value",
        "default": 0.01,
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.initial_progenitor_tumor_cell_e",
        "description": "Initial Progenitor tumor cell E. Sets the initial value of bundled SBML symbol `Progenitor_tumor_cell_E`."
      },
      {
        "name": "initial_differentiated_tumor_cell_d",
        "label": "Differentiated tumor cell D",
        "units": "native SBML value",
        "default": 0.01,
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.initial_differentiated_tumor_cell_d",
        "description": "Initial Differentiated tumor cell D. Sets the initial value of bundled SBML symbol `Differentiated_tumor_cell_D`."
      },
      {
        "name": "initial_cancer_stem_cells_s",
        "label": "Cancer Stem Cell S",
        "units": "native SBML value",
        "default": 1000,
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.initial_cancer_stem_cells_s",
        "description": "Initial Cancer Stem Cell S. Sets the initial value of bundled SBML symbol `Cancer_Stem_Cell_S`."
      },
      {
        "name": "initial_il_6_cell_bound_il_6_r_complex_on_s",
        "label": "IL 6, Cell bound IL 6R complex on S",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.initial_il_6_cell_bound_il_6_r_complex_on_s",
        "description": "Initial IL 6, Cell bound IL 6R complex on S. Sets the initial value of bundled SBML symbol `IL_6__Cell_bound_IL_6R_complex_on_S`."
      },
      {
        "name": "initial_il_6_cell_bound_il_6_r_complex_on_e",
        "label": "IL 6, Cell bound IL 6R complex on E",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.initial_il_6_cell_bound_il_6_r_complex_on_e",
        "description": "Initial IL 6, Cell bound IL 6R complex on E. Sets the initial value of bundled SBML symbol `IL_6__Cell_bound_IL_6R_complex_on_E`."
      },
      {
        "name": "initial_il_6_cell_bound_il_6_r_complex_on_d",
        "label": "IL 6, Cell bound IL 6R complex on D",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.initial_il_6_cell_bound_il_6_r_complex_on_d",
        "description": "Initial IL 6, Cell bound IL 6R complex on D. Sets the initial value of bundled SBML symbol `IL_6__Cell_bound_IL_6R_complex_on_D`."
      }
    ],
    "outputs": [
      {
        "name": "progenitor_tumor_cell_e",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.progenitor_tumor_cell_e",
        "description": "Progenitor tumor cell E observable. Maps to SBML symbol `Progenitor_tumor_cell_E`."
      },
      {
        "name": "differentiated_tumor_cell_d",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.differentiated_tumor_cell_d",
        "description": "Differentiated tumor cell D observable. Maps to SBML symbol `Differentiated_tumor_cell_D`."
      },
      {
        "name": "cancer_stem_cells_s",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.cancer_stem_cells_s",
        "description": "Cancer Stem Cell S observable. Maps to SBML symbol `Cancer_Stem_Cell_S`."
      },
      {
        "name": "il_6_cell_bound_il_6_r_complex_on_s",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.il_6_cell_bound_il_6_r_complex_on_s",
        "description": "IL 6, Cell bound IL 6R complex on S observable. Maps to SBML symbol `IL_6__Cell_bound_IL_6R_complex_on_S`."
      },
      {
        "name": "il_6_cell_bound_il_6_r_complex_on_e",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.il_6_cell_bound_il_6_r_complex_on_e",
        "description": "IL 6, Cell bound IL 6R complex on E observable. Maps to SBML symbol `IL_6__Cell_bound_IL_6R_complex_on_E`."
      },
      {
        "name": "il_6_cell_bound_il_6_r_complex_on_d",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.il_6_cell_bound_il_6_r_complex_on_d",
        "description": "IL 6, Cell bound IL 6R complex on D observable. Maps to SBML symbol `IL_6__Cell_bound_IL_6R_complex_on_D`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Nazari2018 - IL6 mediated stem cell driven tumor growth and targeted treatment Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model_state"
      ],
      "from": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model_summary"
      ],
      "from": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model_species_labels"
      ],
      "from": "oncology_sbml_nazari2018_il6_mediated_stem_cell_driven_tumor_g_biomd0000000819_model.species_labels"
    }
  ],
  "package": "nazari2018-il6-mediated-stem-cell-driven-tumor-growth-a-a1b61cbd",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This a model from the article: A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatmentFereshteh Nazari, Alexander T. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}