Aguda1999 - G2 DNA Damage Checkpoint (Cellcycle) Lab

{
  "io": {
    "inputs": [
      {
        "name": "cdc25_active_total",
        "label": "Cdc25 Active Total",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25_active_total",
        "description": "Controls Cdc25 Active Total in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25_active_total`."
      }
    ],
    "outputs": [
      {
        "name": "cdc25_active",
        "label": "Cdc25 Active",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25_active",
        "description": "Tracks Cdc25 Active in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25_active`."
      },
      {
        "name": "cdc25ps216_active",
        "label": "Cdc25Ps216 Active",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25ps216_active",
        "description": "Tracks Cdc25Ps216 Active in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25ps216_active`."
      },
      {
        "name": "cdc25_inactive",
        "label": "Cdc25 Inactive",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25_inactive",
        "description": "Tracks Cdc25 Inactive in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25_inactive`."
      },
      {
        "name": "cdc25ps216_inactive",
        "label": "Cdc25Ps216 Inactive",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25ps216_inactive",
        "description": "Tracks Cdc25Ps216 Inactive in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25ps216_inactive`."
      },
      {
        "name": "phosphorylated_chk1",
        "label": "Phosphorylated Chk1",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.phosphorylated_chk1",
        "description": "Tracks Phosphorylated Chk1 in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.phosphorylated_chk1`."
      },
      {
        "name": "protein_14_3_3",
        "label": "Protein 14-3-3",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.protein_14_3_3",
        "description": "Tracks Protein 14-3-3 in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.protein_14_3_3`."
      },
      {
        "name": "cdc25ps216_14_3_3_inactive",
        "label": "Cdc25Ps216 14-3-3 Inactive",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25ps216_14_3_3_inactive",
        "description": "Tracks Cdc25Ps216 14-3-3 Inactive in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.cdc25ps216_14_3_3_inactive`."
      },
      {
        "name": "p53_tumor_suppressor",
        "label": "p53 tumor suppressor",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.p53_tumor_suppressor",
        "description": "Tracks p53 tumor suppressor in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.p53_tumor_suppressor`."
      },
      {
        "name": "p21",
        "label": "P21",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.p21",
        "description": "Tracks P21 in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.p21`."
      },
      {
        "name": "maturation_promoting_factor",
        "label": "Maturation-promoting factor",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.maturation_promoting_factor",
        "description": "Tracks Maturation-promoting factor in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.maturation_promoting_factor`."
      },
      {
        "name": "p21_mpf",
        "label": "P21 MPF",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.p21_mpf",
        "description": "Tracks P21 MPF in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.p21_mpf`."
      },
      {
        "name": "pre_mpf",
        "label": "Pre MPF",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.pre_mpf",
        "description": "Tracks Pre MPF in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.pre_mpf`."
      },
      {
        "name": "wee1_inhibitory_kinase",
        "label": "Wee1 inhibitory kinase",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.wee1_inhibitory_kinase",
        "description": "Tracks Wee1 inhibitory kinase in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.wee1_inhibitory_kinase`."
      },
      {
        "name": "chk1_checkpoint_kinase",
        "label": "Chk1 checkpoint kinase",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.chk1_checkpoint_kinase",
        "description": "Tracks Chk1 checkpoint kinase in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.chk1_checkpoint_kinase`."
      },
      {
        "name": "rad3_atm",
        "label": "Rad3 ATM",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.rad3_atm",
        "description": "Tracks Rad3 ATM in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.rad3_atm`."
      },
      {
        "name": "wee1_phosphorylated",
        "label": "Wee1 Phosphorylated",
        "maps_to": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.wee1_phosphorylated",
        "description": "Tracks Wee1 Phosphorylated in the lab model via `cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.wee1_phosphorylated`."
      }
    ]
  },
  "title": "Aguda1999 - G2 DNA Damage Checkpoint (Cellcycle) Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model_state"
      ],
      "from": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model_summary"
      ],
      "from": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model_species_labels"
      ],
      "from": "cellcycle_sbml_aguda1999_g2_dna_damage_checkpoint_biomd0000000704_model.species_labels"
    }
  ],
  "package": "aguda1999-g2-dna-damage-checkpoint-models-cellcycle",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.3",
  "description": "Single-model lab wrapper for Aguda1999 - G2 DNA damage checkpoint. Baltazar D. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}