Yang2006_Methadone_PKmodel Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_methadone_absorption_state",
        "label": "Initial Methadone Absorption State",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.initial_methadone_absorption_state"
      },
      {
        "name": "initial_methadone_concentration",
        "label": "Initial Methadone Concentration",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.initial_methadone_concentration"
      },
      {
        "name": "metabolism_vmax",
        "label": "Metabolism VMAX",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.metabolism_vmax"
      },
      {
        "name": "metabolism_km",
        "label": "Metabolism KM",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.metabolism_km"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.species_labels"
      },
      {
        "name": "methadone_absorption_state",
        "label": "Methadone Absorption State",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.methadone_absorption_state"
      },
      {
        "name": "methadone_concentration",
        "label": "Methadone Concentration",
        "maps_to": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.methadone_concentration"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pharmacokinetics",
    "opioid",
    "physiology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Yang2006_Methadone_PKmodel Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model",
      "parameters": {
        "model_path": "data/MODEL1006230040.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model_state"
      ],
      "from": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model_summary"
      ],
      "from": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model_species_labels"
      ],
      "from": "pharmacology_sbml_yang2006_methadone_pkmodel_model1006230040_model.species_labels"
    }
  ],
  "package": "yang2006-methadone-pk",
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This a model from the article: Population-based analysis of methadone distribution and metabolism using anage-dependent physiologically based pharmacokinetic model. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}