Lopes2025 - NFkB model in Breast Cancer Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_nf_k_b",
        "label": "NF-kB",
        "units": "native SBML value",
        "default": 5893.41991828698,
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.initial_nf_k_b",
        "description": "Initial NF-kB. Sets the initial value of bundled SBML symbol `NFkB`."
      },
      {
        "name": "initial_slug",
        "label": "SLUG",
        "units": "native SBML value",
        "default": 7789508.97608121,
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.initial_slug",
        "description": "Initial SLUG. Sets the initial value of bundled SBML symbol `SLUG`."
      },
      {
        "name": "initial_sip1",
        "label": "SIP1",
        "units": "native SBML value",
        "default": 23581097.7152633,
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.initial_sip1",
        "description": "Initial SIP1. Sets the initial value of bundled SBML symbol `SIP1`."
      },
      {
        "name": "initial_twist1",
        "label": "TWIST1",
        "units": "native SBML value",
        "default": 200834985.025365,
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.initial_twist1",
        "description": "Initial TWIST1. Sets the initial value of bundled SBML symbol `TWIST1`."
      }
    ],
    "outputs": [
      {
        "name": "nf_k_b",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.nf_k_b",
        "description": "NF-kB observable. Maps to SBML symbol `NFkB`."
      },
      {
        "name": "slug",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.slug",
        "description": "SLUG observable. Maps to SBML symbol `SLUG`."
      },
      {
        "name": "sip1",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.sip1",
        "description": "SIP1 observable. Maps to SBML symbol `SIP1`."
      },
      {
        "name": "p65",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.p65",
        "description": "P65 observable. Maps to SBML symbol `p65`."
      },
      {
        "name": "p50",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.p50",
        "description": "P50 observable. Maps to SBML symbol `p50`."
      },
      {
        "name": "twist1",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.twist1",
        "description": "TWIST1 observable. Maps to SBML symbol `TWIST1`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "faithful",
    "oncology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Lopes2025 - NFkB model in Breast Cancer Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model_state"
      ],
      "from": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model_summary"
      ],
      "from": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model_species_labels"
      ],
      "from": "oncology_sbml_lopes2025_nfkb_model_in_breast_cancer_model2508260001_model.species_labels"
    }
  ],
  "package": "lopes2025-nfkb-in-breast-cancer",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Model for the activation of SLUG, SIP1, TWIST1, and NF-κB (subunits p50 and p65). The model exhibits two stationary states (bistability), each corresponding to the gene expression profiles we determin.",
  "schema_version": "2.0"
}