Tortolina2015 - Multiple signalling pathway associated with colorectal cancer Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_raf_ras_gtp",
        "label": "Raf Ras GTP",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.initial_raf_ras_gtp",
        "description": "Initial Raf Ras GTP. Sets the initial value of bundled SBML symbol `mw813e3a30_3dd2_48dc_9b30_f8392d171ad5`."
      },
      {
        "name": "initial_raf_aktp",
        "label": "Raf* AKTP",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.initial_raf_aktp",
        "description": "Initial Raf* AKTP. Sets the initial value of bundled SBML symbol `mwfabf208d_3879_4a2a_b1dc_568efc0f00d8`."
      },
      {
        "name": "initial_ras",
        "label": "Ras",
        "units": "native SBML value",
        "default": 85,
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.initial_ras",
        "description": "Initial Ras. Sets the initial value of bundled SBML symbol `mw33086e75_6e6c_406a_8e47_9e8290ec6c71`."
      },
      {
        "name": "initial_raf",
        "label": "Raf",
        "units": "native SBML value",
        "default": 50,
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.initial_raf",
        "description": "Initial Raf. Sets the initial value of bundled SBML symbol `mw020aa876_35fd_48bc_a111_b4d2c8e30189`."
      },
      {
        "name": "initial_erk",
        "label": "ERK",
        "units": "native SBML value",
        "default": 200,
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.initial_erk",
        "description": "Initial ERK. Sets the initial value of bundled SBML symbol `mw2b09949a_fc27_4cec_a09a_533d7c925f21`."
      },
      {
        "name": "initial_akt",
        "label": "AKT",
        "units": "native SBML value",
        "default": 100,
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.initial_akt",
        "description": "Initial AKT. Sets the initial value of bundled SBML symbol `mwb39c51c6_1b77_4c59_a689_81c9c728255a`."
      }
    ],
    "outputs": [
      {
        "name": "raf_ras_gtp",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.raf_ras_gtp",
        "description": "Raf Ras GTP observable. Maps to SBML symbol `mw813e3a30_3dd2_48dc_9b30_f8392d171ad5`."
      },
      {
        "name": "raf_aktp",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.raf_aktp",
        "description": "Raf* AKTP observable. Maps to SBML symbol `mwfabf208d_3879_4a2a_b1dc_568efc0f00d8`."
      },
      {
        "name": "ras",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.ras",
        "description": "Ras observable. Maps to SBML symbol `mw33086e75_6e6c_406a_8e47_9e8290ec6c71`."
      },
      {
        "name": "raf",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.raf",
        "description": "Raf observable. Maps to SBML symbol `mw020aa876_35fd_48bc_a111_b4d2c8e30189`."
      },
      {
        "name": "erk",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.erk",
        "description": "ERK observable. Maps to SBML symbol `mw2b09949a_fc27_4cec_a09a_533d7c925f21`."
      },
      {
        "name": "akt",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.akt",
        "description": "AKT observable. Maps to SBML symbol `mwb39c51c6_1b77_4c59_a689_81c9c728255a`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "faithful",
    "logical-model",
    "oncology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Tortolina2015 - Multiple signalling pathway associated with colorectal cancer Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model_state"
      ],
      "from": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model_summary"
      ],
      "from": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model_species_labels"
      ],
      "from": "oncology_sbml_tortolina2015_multiple_signalling_pathway_associ_model1601250000_model.species_labels"
    }
  ],
  "package": "tortolina2015-multiple-signalling-pathway-associated-wi-edf1d8e2",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Oncology Tortolina2015Multiple Signalling Pathway Associ Model1601250000Model models core biological dynamics as a OTHER simulation curated from biomodels_ebi (biomodels_ebi:MODEL1601250000), focused on oncolog. When you run it, you can track state over time and compare response patterns across parameter settings.",
  "schema_version": "2.0"
}