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Two-model lab for Guyton1972 Stress Relaxation: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "integration_step",
"maps_to": "guyton1972_stress_relaxation_core.integration_step"
},
{
"name": "parameter_overrides",
"maps_to": "guyton1972_stress_relaxation_core.parameter_overrides"
},
{
"name": "initial_conditions",
"maps_to": "guyton1972_stress_relaxation_core.initial_conditions"
}
],
"outputs": [
{
"name": "scenario_metadata",
"maps_to": "guyton1972_stress_relaxation_scenario.scenario_metadata"
},
{
"name": "state",
"maps_to": "guyton1972_stress_relaxation_core.state"
},
{
"name": "run_summary",
"maps_to": "guyton1972_stress_relaxation_viz.run_summary"
}
]
},
"title": "Guyton1972 Stress Relaxation Lab",
"models": [
{
"path": "models/scenario",
"alias": "guyton1972_stress_relaxation_scenario",
"parameters": {
"schedule": {
"effective_volume": {
"unit": "dimensionless",
"label": "effective volume",
"active": true,
"baseline": 0.743224,
"recovery": 0.743224,
"challenge": 0.8547075999999999,
"description": "Scenario-controlled effective volume value."
},
"stress_relaxation_gain": {
"unit": "dimensionless",
"label": "stress relaxation gain",
"active": false,
"baseline": 5,
"recovery": 5,
"challenge": 5,
"description": "Scenario-controlled stress relaxation gain value."
},
"stress_relaxation_gain_2": {
"unit": "dimensionless",
"label": "stress relaxation gain 2",
"active": false,
"baseline": 10000,
"recovery": 10000,
"challenge": 10000,
"description": "Scenario-controlled stress relaxation gain 2 value."
}
},
"scenario_name": "Effective volume challenge",
"baseline_until": 0.25,
"challenge_until": 0.75,
"scenario_description": "Baseline is followed by a effective volume challenge and recovery period."
}
},
{
"path": "./models/core",
"alias": "guyton1972_stress_relaxation_core",
"parameters": {
"model_path": "data/MODEL0910896131.xml",
"integration_step": 0.001
}
},
{
"path": "./models/viz",
"alias": "guyton1972_stress_relaxation_viz",
"parameters": {
"lab_title": "Guyton1972 Stress Relaxation",
"lab_question": "Does vascular stress relaxation buffer pressure?",
"integration_step": 0.001
}
}
],
"wiring": [
{
"to": [
"guyton1972_stress_relaxation_core.effective_volume"
],
"from": "guyton1972_stress_relaxation_scenario.effective_volume"
},
{
"to": [
"guyton1972_stress_relaxation_core.stress_relaxation_gain"
],
"from": "guyton1972_stress_relaxation_scenario.stress_relaxation_gain"
},
{
"to": [
"guyton1972_stress_relaxation_core.stress_relaxation_gain_2"
],
"from": "guyton1972_stress_relaxation_scenario.stress_relaxation_gain_2"
},
{
"to": [
"guyton1972_stress_relaxation_viz.scenario_metadata"
],
"from": "guyton1972_stress_relaxation_scenario.scenario_metadata"
},
{
"to": [
"guyton1972_stress_relaxation_viz.state"
],
"from": "guyton1972_stress_relaxation_core.state"
},
{
"to": [
"guyton1972_stress_relaxation_viz.species_labels"
],
"from": "guyton1972_stress_relaxation_core.species_labels"
}
],
"package": "guyton1972-stress-relaxation",
"runtime": {
"duration": 1,
"initial_inputs": {
"guyton1972_stress_relaxation_core": {
"integration_step": 0.001,
"initial_conditions": {
"payload": {}
},
"parameter_overrides": {
"payload": {}
}
}
},
"communication_step": 0.001
},
"version": "1.0.0",
"description": "Two-model lab for Guyton1972 Stress Relaxation: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.001
Runs
Total0
Completed0
Failed0
Metadata
Packageguyton1972-stress-relaxation
Created2026-05-14
Updated2026-06-13
cardiovascularscenariostimulussbmlbiomodels_ebifaithfulvisualizationother