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Proctor2013 - Cartilage breakdown, interventions to reduce collagen release The molecular pathways involved in cartilage breakdown is studied using this model to examine possible interventions to redu. It can be used to explore systemsbiology proctor2013 cartilage breakdown interventions to dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_traf6",
"label": "Initial Traf6",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.initial_traf6",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TRAF6`."
},
{
"name": "initial_stat3_cyt",
"label": "Initial Stat3 Cyt",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.initial_stat3_cyt",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `STAT3_cyt`."
},
{
"name": "initial_timp3_mrna",
"label": "Initial Timp3 MRNA",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.initial_timp3_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TIMP3_mRNA`."
},
{
"name": "initial_timp1_mrna",
"label": "Initial Timp1 MRNA",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.initial_timp1_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TIMP1_mRNA`."
},
{
"name": "initial_c_jun_mrna",
"label": "Initial C Jun MRNA",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.initial_c_jun_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `cJun_mRNA`."
},
{
"name": "initial_traf6_pp4",
"label": "Initial Traf6 PP4",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.initial_traf6_pp4",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TRAF6_PP4`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.species_labels"
},
{
"name": "traf6",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.traf6"
},
{
"name": "stat3_cyt",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.stat3_cyt"
},
{
"name": "timp3_mrna",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.timp3_mrna"
},
{
"name": "timp1_mrna",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.timp1_mrna"
},
{
"name": "c_jun_mrna",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.c_jun_mrna"
},
{
"name": "traf6_pp4",
"maps_to": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.traf6_pp4"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Proctor2013 Cartilage Breakdown Interventions To Reduce Collagen Relea Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model_state"
],
"from": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.state"
},
{
"to": [
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],
"from": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model_species_labels"
],
"from": "systemsbiology_sbml_proctor2013_cartilage_breakdown_interventions_to_biomd0000000504_model.species_labels"
}
],
"package": "proctor2013-cartilage-breakdown-interventions-to-reduce-226f7749",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Proctor2013 - Cartilage breakdown, interventions to reduce collagen release The molecular pathways involved in cartilage breakdown is studied using this model to examine possible interventions to redu. It can be used to explore systemsbiology proctor2013 cartilage breakdown interventions to dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageproctor2013-cartilage-breakdown-interventions-to-reduce-226f7749
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother