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The paper describes a model on the trastuzumab-induced immune response in murine(mouse) HER2+ breast cancer.Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical mode. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_tumor_observable_1",
"label": "Initial Unresolved Tumor Observable 1",
"units": "substance",
"default": 0.2,
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.initial_unresolved_tumor_observable_1",
"description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `T`."
},
{
"name": "initial_unresolved_tumor_observable_2",
"label": "Initial Unresolved Tumor Observable 2",
"units": "substance",
"default": 0.071,
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.initial_unresolved_tumor_observable_2",
"description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `I`."
},
{
"name": "initial_unresolved_tumor_observable_3",
"label": "Initial Unresolved Tumor Observable 3",
"units": "substance",
"default": 0.12,
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.initial_unresolved_tumor_observable_3",
"description": "Initial Unresolved Tumor Observable 3. Sets the initial value of bundled SBML species `V`."
},
{
"name": "initial_unresolved_tumor_observable_4",
"label": "Initial Unresolved Tumor Observable 4",
"units": "substance",
"default": 0.1,
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.initial_unresolved_tumor_observable_4",
"description": "Initial Unresolved Tumor Observable 4. Sets the initial value of bundled SBML species `N`."
},
{
"name": "initial_unresolved_tumor_observable_5",
"label": "Initial Unresolved Tumor Observable 5",
"units": "substance",
"default": 0.18,
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.initial_unresolved_tumor_observable_5",
"description": "Initial Unresolved Tumor Observable 5. Sets the initial value of bundled SBML species `H`."
}
],
"outputs": [
{
"name": "unresolved_tumor_observable_1",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.unresolved_tumor_observable_1"
},
{
"name": "unresolved_tumor_observable_2",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.unresolved_tumor_observable_2"
},
{
"name": "unresolved_tumor_observable_3",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.unresolved_tumor_observable_3"
},
{
"name": "unresolved_tumor_observable_4",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.unresolved_tumor_observable_4"
},
{
"name": "unresolved_tumor_observable_5",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.unresolved_tumor_observable_5"
},
{
"name": "state",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.species_labels"
}
]
},
"title": "Jarrett2018 - trastuzumab-induced immune response in murine HER2+ breast cancer model Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model_state"
],
"from": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.state"
},
{
"to": [
"visualisation.immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model_summary"
],
"from": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model_species_labels"
],
"from": "immunology_sbml_jarrett2018_trastuzumab_induced_immune_response_biomd0000000745_model.species_labels"
}
],
"package": "jarrett2018-trastuzumab-induced-immune-response-in-muri-bf10e3d5",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "The paper describes a model on the trastuzumab-induced immune response in murine(mouse) HER2+ breast cancer.Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical mode. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagejarrett2018-trastuzumab-induced-immune-response-in-muri-bf10e3d5
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother