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The model is described in the paper by Wu and Chang (2006). Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH3 cells.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_er_ca_concentration",
"label": "Initial Er Ca Concentration",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.initial_er_ca_concentration",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `cer`."
},
{
"name": "initial_cytosolic_free_ca_concentration",
"label": "Initial Cytosolic Free Ca Concentration",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.initial_cytosolic_free_ca_concentration",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `c`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.species_labels"
},
{
"name": "er_ca_concentration",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.er_ca_concentration"
},
{
"name": "cytosolic_free_ca_concentration",
"maps_to": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.cytosolic_free_ca_concentration"
}
]
},
"tags": [
"metabolism",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Wu2006 K Channel Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model_state"
],
"from": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model_summary"
],
"from": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model_species_labels"
],
"from": "systemsbiology_sbml_wu2006_k_channel_biomd0000000124_model.species_labels"
}
],
"package": "wu2006-k-channel",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "The model is described in the paper by Wu and Chang (2006). Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH3 cells.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagewu2006-k-channel
Created2026-05-17
Updated2026-06-13
metabolismsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother