Kraan199_Kinetics of Cortisol Metabolism and Excretion. Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_circulating_cortisol",
        "label": "Initial Circulating Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.initial_circulating_cortisol"
      },
      {
        "name": "initial_urinary_excreted_cortisol",
        "label": "Initial Urinary Excreted Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.initial_urinary_excreted_cortisol"
      },
      {
        "name": "initial_non_urinary_excreted_cortisol",
        "label": "Initial Non Urinary Excreted Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.initial_non_urinary_excreted_cortisol"
      },
      {
        "name": "initial_metabolizing_tissue_cortisol",
        "label": "Initial Metabolizing Tissue Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.initial_metabolizing_tissue_cortisol"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.species_labels"
      },
      {
        "name": "circulating_cortisol",
        "label": "Circulating Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.circulating_cortisol"
      },
      {
        "name": "metabolizing_tissue_cortisol",
        "label": "Metabolizing Tissue Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.metabolizing_tissue_cortisol"
      },
      {
        "name": "urinary_excreted_cortisol",
        "label": "Urinary Excreted Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.urinary_excreted_cortisol"
      },
      {
        "name": "non_urinary_excreted_cortisol",
        "label": "Non Urinary Excreted Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.non_urinary_excreted_cortisol"
      },
      {
        "name": "gallbladder_intestinal_cortisol",
        "label": "Gallbladder Intestinal Cortisol",
        "maps_to": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.gallbladder_intestinal_cortisol"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pharmacokinetics",
    "endocrine",
    "metabolism",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Kraan199_Kinetics of Cortisol Metabolism and Excretion. Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model",
      "parameters": {
        "model_path": "data/BIOMD0000000916.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model_state"
      ],
      "from": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model_summary"
      ],
      "from": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model_species_labels"
      ],
      "from": "pharmacology_sbml_kraan199_kinetics_of_cortisol_metabolism_and_exc_biomd0000000916_model.species_labels"
    }
  ],
  "package": "kraan199-cortisol-metabolism",
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "A new model is proposed to study the kinetics of [3H]cortisol metabolism by using urinary data only. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}