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This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE 2011; 6(7): e22038. It can be used to explore systemsbiology proctor2011 proteinhomeostasis normalcondition BioModels0000000344 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_nat_p",
"label": "Initial Nat P",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.initial_nat_p",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `NatP`."
},
{
"name": "initial_model_state_atp",
"label": "Initial Model State ATP",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.initial_model_state_atp",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ATP`."
},
{
"name": "initial_model_state_adp",
"label": "Initial Model State ADP",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.initial_model_state_adp",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ADP`."
},
{
"name": "initial_pi_death",
"label": "Initial Pi Death",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.initial_pi_death",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PIDeath`."
},
{
"name": "initial_p38_death",
"label": "Initial P38 Death",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.initial_p38_death",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p38Death`."
},
{
"name": "initial_jnk_death",
"label": "Initial Jnk Death",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.initial_jnk_death",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `JNKDeath`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.species_labels"
},
{
"name": "nat_p",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.nat_p"
},
{
"name": "atp",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.atp"
},
{
"name": "adp",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.adp"
},
{
"name": "pi_death",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.pi_death"
},
{
"name": "p38_death",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.p38_death"
},
{
"name": "jnk_death",
"maps_to": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.jnk_death"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Proctor2011 Proteinhomeostasis Normalcondition Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model_state"
],
"from": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model_summary"
],
"from": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model_species_labels"
],
"from": "systemsbiology_sbml_proctor2011_proteinhomeostasis_normalcondition_biomd0000000344_model.species_labels"
}
],
"package": "proctor2011-proteinhomeostasis-normalcondition",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE 2011; 6(7): e22038. It can be used to explore systemsbiology proctor2011 proteinhomeostasis normalcondition BioModels0000000344 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageproctor2011-proteinhomeostasis-normalcondition
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother