Zhang2018 - Cell cycle commitment in hypoxia Lab

{
  "io": {
    "inputs": [
      {
        "name": "oxygen",
        "label": "Oxygen",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.oxygen",
        "description": "Controls Oxygen in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.oxygen`."
      }
    ],
    "outputs": [
      {
        "name": "hif_1_alpha_myc",
        "label": "HIF-1 alpha Myc",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_1_alpha_myc",
        "description": "Tracks HIF-1 alpha Myc in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_1_alpha_myc`."
      },
      {
        "name": "hif_2_alpha_myc",
        "label": "HIF-2 alpha Myc",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_2_alpha_myc",
        "description": "Tracks HIF-2 alpha Myc in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_2_alpha_myc`."
      },
      {
        "name": "e2f_transcription_factor",
        "label": "E2F transcription factor",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.e2f_transcription_factor",
        "description": "Tracks E2F transcription factor in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.e2f_transcription_factor`."
      },
      {
        "name": "double_phosphorylated_cyclin_d",
        "label": "Double-phosphorylated Cyclin D",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.double_phosphorylated_cyclin_d",
        "description": "Tracks Double-phosphorylated Cyclin D in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.double_phosphorylated_cyclin_d`."
      },
      {
        "name": "cyclin_d",
        "label": "Cyclin D",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.cyclin_d",
        "description": "Tracks Cyclin D in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.cyclin_d`."
      },
      {
        "name": "cyclin_e",
        "label": "Cyclin E",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.cyclin_e",
        "description": "Tracks Cyclin E in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.cyclin_e`."
      },
      {
        "name": "phosphorylated_rb",
        "label": "Phosphorylated Rb",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.phosphorylated_rb",
        "description": "Tracks Phosphorylated Rb in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.phosphorylated_rb`."
      },
      {
        "name": "unphosphorylated_rb",
        "label": "Unphosphorylated Rb",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.unphosphorylated_rb",
        "description": "Tracks Unphosphorylated Rb in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.unphosphorylated_rb`."
      },
      {
        "name": "myc_transcription_factor",
        "label": "Myc transcription factor",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.myc_transcription_factor",
        "description": "Tracks Myc transcription factor in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.myc_transcription_factor`."
      },
      {
        "name": "e2f_rb",
        "label": "E2F Rb",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.e2f_rb",
        "description": "Tracks E2F Rb in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.e2f_rb`."
      },
      {
        "name": "rb_tumor_suppressor",
        "label": "Rb tumor suppressor",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.rb_tumor_suppressor",
        "description": "Tracks Rb tumor suppressor in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.rb_tumor_suppressor`."
      },
      {
        "name": "double_phosphorylation_signal",
        "label": "Double phosphorylation signal",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.double_phosphorylation_signal",
        "description": "Tracks Double phosphorylation signal in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.double_phosphorylation_signal`."
      },
      {
        "name": "double_phosphorylated_cyclin_e",
        "label": "Double-phosphorylated Cyclin E",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.double_phosphorylated_cyclin_e",
        "description": "Tracks Double-phosphorylated Cyclin E in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.double_phosphorylated_cyclin_e`."
      },
      {
        "name": "oxygen_dependent_degradation_factor",
        "label": "Oxygen-dependent degradation factor",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.oxygen_dependent_degradation_factor",
        "description": "Tracks Oxygen-dependent degradation factor in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.oxygen_dependent_degradation_factor`."
      },
      {
        "name": "hif_1_alpha",
        "label": "HIF-1 alpha",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_1_alpha",
        "description": "Tracks HIF-1 alpha in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_1_alpha`."
      },
      {
        "name": "hif_2_alpha",
        "label": "HIF-2 alpha",
        "maps_to": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_2_alpha",
        "description": "Tracks HIF-2 alpha in the lab model via `cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.hif_2_alpha`."
      }
    ]
  },
  "title": "Zhang2018 - Cell cycle commitment in hypoxia Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model_state"
      ],
      "from": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model_summary"
      ],
      "from": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model_species_labels"
      ],
      "from": "cellcycle_sbml_zhang2018_cell_cycle_commitment_in_hypoxia_model1812060002_model.species_labels"
    }
  ],
  "package": "zhang2018-hypoxia-commitment",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Single-model lab wrapper for Zhang2018 - Cell cycle commitment in hypoxia. Cell Cycle Zhang2018Cell Cycle Commitment In Hypoxia Model1812060002Model represents core biological mechanisms from biomodels_ebi reference biomodels_ebi:MODEL1812060002. When you run it, you can inspect state and compare temporal behavior between baseline and adjusted inputs.",
  "schema_version": "2.0"
}