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Its a mathematcial model explaining regulation of HIF via FIH and oxygen. Model is further validated by Experimental data and various hypothesis has been tested on the same.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_mrna",
"label": "Initial MRNA",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.initial_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mRNA`."
},
{
"name": "initial_protein",
"label": "Initial Protein",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.initial_protein",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Protein`."
},
{
"name": "initial_luciferase",
"label": "Initial Luciferase",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.initial_luciferase",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Luciferase`."
},
{
"name": "initial_vhl_n",
"label": "Initial Vhl N",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.initial_vhl_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `VHL_n`."
},
{
"name": "initial_fih_n",
"label": "Initial Fih N",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.initial_fih_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `FIH_n`."
},
{
"name": "initial_phd_n",
"label": "Initial Phd N",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.initial_phd_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PHD_n`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.species_labels"
},
{
"name": "mrna",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.mrna"
},
{
"name": "protein",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.protein"
},
{
"name": "luciferase",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.luciferase"
},
{
"name": "vhl_n",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.vhl_n"
},
{
"name": "fih_n",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.fih_n"
},
{
"name": "phd_n",
"maps_to": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.phd_n"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Nguyen2013 Dynamic Model Of Hif Regulation In Hypoxia Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model_state"
],
"from": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model_summary"
],
"from": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model_species_labels"
],
"from": "systemsbiology_sbml_nguyen2013_dynamic_model_of_hif_regulation_in_hy_model1912100004_model.species_labels"
}
],
"package": "nguyen2013-dynamic-model-of-hif-regulation-in-hypoxia",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Its a mathematcial model explaining regulation of HIF via FIH and oxygen. Model is further validated by Experimental data and various hypothesis has been tested on the same.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagenguyen2013-dynamic-model-of-hif-regulation-in-hypoxia
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother