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Source-faithful physiology lab for Kholodenko, Demin, Moehren, Hoek, 1999. Public controls and outputs are mapped to real source symbols for signalling physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_concentration_g_s",
"label": "Initial Concentration G S (source G_S)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.initial_concentration_g_s",
"description": "Initial value for Concentration G S (source G_S). Maps to source symbol `G_S`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state.",
"accepted_units": [
"nanomolar"
]
},
{
"name": "initial_concentration_r",
"label": "Initial Concentration R (source R)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.initial_concentration_r",
"description": "Initial value for Concentration R (source R). Maps to source symbol `R`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state.",
"accepted_units": [
"nanomolar"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.variable_labels"
},
{
"name": "concentration_g_s",
"label": "Concentration G S (source G_S)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.concentration_g_s",
"description": "Concentration G S (source G_S). Maps to source symbol `G_S`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state."
},
{
"name": "concentration_r",
"label": "Concentration R (source R)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.concentration_r",
"description": "Concentration R (source R). Maps to source symbol `R`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state."
},
{
"name": "concentration_r2",
"label": "Concentration R2 (source R2)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.concentration_r2",
"description": "Concentration R2 (source R2). Maps to source symbol `R2`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state."
},
{
"name": "concentration_r_g",
"label": "Concentration R G (source R_G)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.concentration_r_g",
"description": "Concentration R G (source R_G). Maps to source symbol `R_G`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state."
},
{
"name": "concentration_r_pl",
"label": "Concentration R Pl (source R_PL)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.concentration_r_pl",
"description": "Concentration R Pl (source R_PL). Maps to source symbol `R_PL`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state."
},
{
"name": "concentration_r_sh",
"label": "Concentration R Sh (source R_Sh)",
"maps_to": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.concentration_r_sh",
"description": "Concentration R Sh (source R_Sh). Maps to source symbol `R_Sh`. Units: nanomolar. Naming evidence: amount concentration units identify a concentration state."
}
]
},
"title": "Kholodenko1999 - Quantification Short Term Signaling By Epi Kholodenkodemi Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model",
"parameters": {
"model_path": "data/kholodenko_demin_moehren_hoek_1999.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model_state"
],
"from": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.state"
},
{
"to": [
"visualisation.physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model_summary"
],
"from": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model_trajectory"
],
"from": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model_variable_labels"
],
"from": "physiology_cellml_kholodenko_demin_moehren_hoek_1999_kholodenkodeminmoehrenhoek1999_model.variable_labels"
}
],
"package": "kholodenko1999-quantification-short-term-signaling-by-e-8837dbd6",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Source-faithful physiology lab for Kholodenko, Demin, Moehren, Hoek, 1999. Public controls and outputs are mapped to real source symbols for signalling physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagekholodenko1999-quantification-short-term-signaling-by-e-8837dbd6
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother