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DallePazze2014 - Cellular senescene-inducedmitochondrial dysfunction This model is described in the article: Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interv. It can be used to explore systemsbiology dallepezze2014 cellular senescene induced mitoch dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "akt_s473_phos_by_insulin",
"label": "Akt S473 Phos By Insulin",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.akt_s473_phos_by_insulin",
"description": "Source parameter exposed because its SBML label indicates a boundary, stimulus, dose, ligand, protocol, substrate, or environmental control. Maps to SBML symbol `Akt_S473_phos_by_insulin`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.species_labels"
},
{
"name": "m_tor_p_s2448_obs",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.m_tor_p_s2448_obs"
},
{
"name": "m_torc1_p_s2448",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.m_torc1_p_s2448"
},
{
"name": "m_torc1",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.m_torc1"
},
{
"name": "mito_mass_turnover",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.mito_mass_turnover"
},
{
"name": "fox_o3a_total_obs",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.fox_o3a_total_obs"
},
{
"name": "mito_membr_pot_new",
"maps_to": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.mito_membr_pot_new"
}
]
},
"tags": [
"metabolism",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Dallepezze2014 Cellular Senescene Induced Mitochondrial Dysfunction Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model_state"
],
"from": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model_summary"
],
"from": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model_species_labels"
],
"from": "systemsbiology_sbml_dallepezze2014_cellular_senescene_induced_mitoch_biomd0000000582_model.species_labels"
}
],
"package": "dallepezze2014-cellular-senescene-induced-mitochondrial-0cb31077",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "DallePazze2014 - Cellular senescene-inducedmitochondrial dysfunction This model is described in the article: Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interv. It can be used to explore systemsbiology dallepezze2014 cellular senescene induced mitoch dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagedallepezze2014-cellular-senescene-induced-mitochondrial-0cb31077
Created2026-05-17
Updated2026-06-13
metabolismsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother