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A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice David C Whitcomb, G Bard Ermentrout, Pancreas 2004 29:e30-40; PubMedID: 15257112 Abstrac. It can be used to explore systemsbiology whitcomb2004 bicarbonate pancreas BioModels0000000327 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_na",
"label": "Initial Model State Na",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_model_state_na",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `nb`."
},
{
"name": "initial_model_state_cl",
"label": "Initial Model State Cl",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_model_state_cl",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `cb`."
},
{
"name": "initial_model_state_cl_2",
"label": "Initial Model State Cl 2",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_model_state_cl_2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ci`."
},
{
"name": "initial_hco3",
"label": "Initial Hco3",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_hco3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `bl`."
},
{
"name": "initial_hco3_2",
"label": "Initial Hco3 2",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_hco3_2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `bb`."
},
{
"name": "initial_hco3_3",
"label": "Initial Hco3 3",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.initial_hco3_3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `bi`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.species_labels"
},
{
"name": "model_state_na",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.model_state_na"
},
{
"name": "model_state_cl",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.model_state_cl"
},
{
"name": "model_state_cl_2",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.model_state_cl_2"
},
{
"name": "hco3",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.hco3"
},
{
"name": "hco3_2",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.hco3_2"
},
{
"name": "hco3_3",
"maps_to": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.hco3_3"
}
]
},
"tags": [
"generegulation",
"immunology",
"physiology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Whitcomb2004 Bicarbonate Pancreas Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model_state"
],
"from": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model_summary"
],
"from": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model_species_labels"
],
"from": "systemsbiology_sbml_whitcomb2004_bicarbonate_pancreas_biomd0000000327_model.species_labels"
}
],
"package": "whitcomb2004-bicarbonate-pancreas",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice David C Whitcomb, G Bard Ermentrout, Pancreas 2004 29:e30-40; PubMedID: 15257112 Abstrac. It can be used to explore systemsbiology whitcomb2004 bicarbonate pancreas BioModels0000000327 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagewhitcomb2004-bicarbonate-pancreas
Created2026-05-17
Updated2026-06-13
generegulationimmunologyphysiologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother